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Article: Late onset hypothyroidism after subtotal thyroidectomy for hyperthyroidism: Implications for long term follow-up

TitleLate onset hypothyroidism after subtotal thyroidectomy for hyperthyroidism: Implications for long term follow-up
Authors
Issue Date1983
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk
Citation
British Journal Of Surgery, 1983, v. 70 n. 12, p. 740-743 How to Cite?
AbstractA follow-up register has been used in Aberdeen and Dundee to record early and late onset hypothyroidism occurring in a large population of post-thyroidectomy patients treated for hyperthyroidism. In one centre, in a total of 1170 patients, the prevalence of postoperative hypothyroidism, at the time of entry to the register, was 41 per cent. Of these early cases of hypothyroidism 93 per cent occurred within 18 months of operation. Results are presented from a 12-year prospective study of patients treated in two centres, who were euthyroid when entered on the follow-up register. In one centre, based on 683 patients, the 10-year incidence of late onset hypothyroidism estimated by actuarial methods was 7.4 per cent (95 per cent confidence limits, 3.8 - 11.1); in the other centre with 156 patients the 5-year incidence was 10.8 per cent (95 per cent confidence limits, 3-18.6). The minimum predicted annual incidence is 1 per cent. Large thyroid remnants do not protect some patients against early or late postoperative hypothyroidism but do lead to an increased risk of recurrent hyperthyroidism. Hypothyroidism after subtotal thyroidectomy for hyperthyroidism shows a bimodal pattern and this study emphasizes the need to maintain life-long follow-up.
Persistent Identifierhttp://hdl.handle.net/10722/151436
ISSN
2015 Impact Factor: 5.596
2015 SCImago Journal Rankings: 2.966
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHedley, AJen_US
dc.contributor.authorBewsher, PDen_US
dc.contributor.authorJones, SJen_US
dc.date.accessioned2012-06-26T06:23:24Z-
dc.date.available2012-06-26T06:23:24Z-
dc.date.issued1983en_US
dc.identifier.citationBritish Journal Of Surgery, 1983, v. 70 n. 12, p. 740-743en_US
dc.identifier.issn0007-1323en_US
dc.identifier.urihttp://hdl.handle.net/10722/151436-
dc.description.abstractA follow-up register has been used in Aberdeen and Dundee to record early and late onset hypothyroidism occurring in a large population of post-thyroidectomy patients treated for hyperthyroidism. In one centre, in a total of 1170 patients, the prevalence of postoperative hypothyroidism, at the time of entry to the register, was 41 per cent. Of these early cases of hypothyroidism 93 per cent occurred within 18 months of operation. Results are presented from a 12-year prospective study of patients treated in two centres, who were euthyroid when entered on the follow-up register. In one centre, based on 683 patients, the 10-year incidence of late onset hypothyroidism estimated by actuarial methods was 7.4 per cent (95 per cent confidence limits, 3.8 - 11.1); in the other centre with 156 patients the 5-year incidence was 10.8 per cent (95 per cent confidence limits, 3-18.6). The minimum predicted annual incidence is 1 per cent. Large thyroid remnants do not protect some patients against early or late postoperative hypothyroidism but do lead to an increased risk of recurrent hyperthyroidism. Hypothyroidism after subtotal thyroidectomy for hyperthyroidism shows a bimodal pattern and this study emphasizes the need to maintain life-long follow-up.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uken_US
dc.relation.ispartofBritish Journal of Surgeryen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperthyroidism - Surgeryen_US
dc.subject.meshHypothyroidism - Drug Therapy - Etiologyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshThyroidectomy - Adverse Effectsen_US
dc.subject.meshThyroxine - Therapeutic Useen_US
dc.subject.meshTime Factorsen_US
dc.titleLate onset hypothyroidism after subtotal thyroidectomy for hyperthyroidism: Implications for long term follow-upen_US
dc.typeArticleen_US
dc.identifier.emailHedley, AJ:hrmrajh@hkucc.hku.hken_US
dc.identifier.authorityHedley, AJ=rp00357en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6640256-
dc.identifier.scopuseid_2-s2.0-0021029114en_US
dc.identifier.volume70en_US
dc.identifier.issue12en_US
dc.identifier.spage740en_US
dc.identifier.epage743en_US
dc.identifier.isiWOS:A1983RX18800013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHedley, AJ=7102584095en_US
dc.identifier.scopusauthoridBewsher, PD=7004559702en_US
dc.identifier.scopusauthoridJones, SJ=7405931706en_US

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