File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Studies of lymphocyte subpopulations and immunoglobulin production in IgA nephropathy

TitleStudies of lymphocyte subpopulations and immunoglobulin production in IgA nephropathy
Authors
Issue Date1987
PublisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.com
Citation
Clinical Nephrology, 1987, v. 28 n. 6, p. 281-287 How to Cite?
AbstractThis work was undertaken to examine the immunoregulation of T lymphocytes in patients with IgA nephropathy. Fifty patients and thirty-seven control subjects were studied in an infection-free interval. T lymphocyte subpopulations were determined using OKT monoclonal antibodies against helper (OKT4) and suppressor (OKT8) T cell subsets. The proportions of T lymphocyte subpopulations did not differ between patients and controls. Patients with significant renal impairment demonstrated a reduced OKT4/T8 ratio (p < 0.001) due to an absolute reduction of T helper cells (p < 0.02) and an increase of T suppressor cells (p < 0.001). Longitudinal studies performed in 13 patients revealed consistent findings during clinical quiescence. However, synpharyngitic macroscopic haematuria was associated with a rise in T4 positive cells and a simultaneous reduction of T8 positive cells; these changes reverted to pre-infection values when the infection subsided. Functional studies assessing T lymphocyte activities including in vitro immunoglobulin synthesis by cultured peripheral blood mononuclear cells, thymidine uptake by cultured lymphocytes and T lymphocytes activation with expression of interleukin-2 receptors were measured in unstimulated and mitogen stimulated cultures. No significant difference between patients with IgA nephropathy in clinical quiescence and the control subjects was demonstrated. Our results failed to support a shift in the immuno-regulatory T lymphocyte subpopulations during clinical quiescence but a more profound defect in immunoregulation may probably occur during clinical exacerbation.
Persistent Identifierhttp://hdl.handle.net/10722/149476
ISSN
2015 Impact Factor: 1.065
2015 SCImago Journal Rankings: 0.498
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLai, FMen_HK
dc.contributor.authorChui, SHen_HK
dc.contributor.authorChan, YMen_HK
dc.contributor.authorTsao, GSWen_HK
dc.contributor.authorLeung, KNen_HK
dc.contributor.authorLam, CWKen_HK
dc.date.accessioned2012-06-26T05:54:12Z-
dc.date.available2012-06-26T05:54:12Z-
dc.date.issued1987en_HK
dc.identifier.citationClinical Nephrology, 1987, v. 28 n. 6, p. 281-287en_HK
dc.identifier.issn0301-0430en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149476-
dc.description.abstractThis work was undertaken to examine the immunoregulation of T lymphocytes in patients with IgA nephropathy. Fifty patients and thirty-seven control subjects were studied in an infection-free interval. T lymphocyte subpopulations were determined using OKT monoclonal antibodies against helper (OKT4) and suppressor (OKT8) T cell subsets. The proportions of T lymphocyte subpopulations did not differ between patients and controls. Patients with significant renal impairment demonstrated a reduced OKT4/T8 ratio (p < 0.001) due to an absolute reduction of T helper cells (p < 0.02) and an increase of T suppressor cells (p < 0.001). Longitudinal studies performed in 13 patients revealed consistent findings during clinical quiescence. However, synpharyngitic macroscopic haematuria was associated with a rise in T4 positive cells and a simultaneous reduction of T8 positive cells; these changes reverted to pre-infection values when the infection subsided. Functional studies assessing T lymphocyte activities including in vitro immunoglobulin synthesis by cultured peripheral blood mononuclear cells, thymidine uptake by cultured lymphocytes and T lymphocytes activation with expression of interleukin-2 receptors were measured in unstimulated and mitogen stimulated cultures. No significant difference between patients with IgA nephropathy in clinical quiescence and the control subjects was demonstrated. Our results failed to support a shift in the immuno-regulatory T lymphocyte subpopulations during clinical quiescence but a more profound defect in immunoregulation may probably occur during clinical exacerbation.en_HK
dc.languageengen_US
dc.publisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.comen_HK
dc.relation.ispartofClinical Nephrologyen_HK
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshGlomerulonephritis, Iga - Immunology - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins - Biosynthesisen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshT-Lymphocytes - Classification - Pathologyen_US
dc.subject.meshT-Lymphocytes, Helper-Inducer - Immunologyen_US
dc.subject.meshT-Lymphocytes, Regulatory - Immunologyen_US
dc.titleStudies of lymphocyte subpopulations and immunoglobulin production in IgA nephropathyen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailTsao, GSW: gswtsao@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityTsao, GSW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2964968-
dc.identifier.scopuseid_2-s2.0-0023608283en_HK
dc.identifier.volume28en_HK
dc.identifier.issue6en_HK
dc.identifier.spage281en_HK
dc.identifier.epage287en_HK
dc.identifier.isiWOS:A1987L388600004-
dc.publisher.placeMünchen-Deisenhofen, Germanyen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLai, FM=7202559720en_HK
dc.identifier.scopusauthoridChui, SH=7007130589en_HK
dc.identifier.scopusauthoridChan, YM=14033791900en_HK
dc.identifier.scopusauthoridTsao, GSW=7102813116en_HK
dc.identifier.scopusauthoridLeung, KN=36946024900en_HK
dc.identifier.scopusauthoridLam, CWK=8531362100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats