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Article: Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke

TitleNaringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke
Authors
KeywordsAirway hyperresponsiveness
Anti-inflammation
Cough
Lipoxin A4
Naringin
Smoke
Issue Date2012
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimp
Citation
International Immunopharmacology, 2012, v. 13 n. 3, p. 301-307 How to Cite?
AbstractNaringin is a flavanone with various bioactivities including expectorant effect, antitussive effect and inhibitory effects on asthma and acute lung injury. In present study we examined the effects of naringin on enhanced cough, airway hyperresponsiveness (AHR) and airway inflammation in chronic cigarette smoke (CS) exposure-induced chronic bronchitis in guinea pigs. To achieve this, guinea pigs were exposed to CS for 8 weeks (10 cigarettes/day, 6 days/week). Oral administration of naringin (9.2, 18.4 and 36.8 mg/kg) significantly attenuated the enhanced cough and AHR in smoke-exposed guinea pigs, reduced the concentrations of interleukin-8 (IL-8), leukotriene B4 (LTB4) and tumor necrosis factor-α (TNF-α) in bronchoalveolar lavage fluid (BALF) and decreased the myeloperoxidase (MPO) activity in both BALF and lung tissue, but did not significantly decrease the leukocytes in BALF. Naringin also improved superoxidase dismutase (SOD) activity in lung tissue and increased the content of lipoxin A4 (LXA4) in BALF in this guinea pig model of chronic bronchitis. These results suggested that naringin exhibited antitussive, anti-AHR and anti-inflammation effects on chronic CS exposure-induced chronic bronchitis in guinea pigs, and may possess novel therapeutic potential in the treatment of chronic bronchitis. © 2012 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149301
ISSN
2015 Impact Factor: 2.551
2015 SCImago Journal Rankings: 0.941
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China81173475
Funding Information:

We would like to thank Dr. Hong-Tao Li, Yan-Chao Zhao and Hong Zhang for their technical and scientific assistance. This study was supported by the National Natural Science Foundation of China (No. 81173475).

References

 

DC FieldValueLanguage
dc.contributor.authorLuo, YLen_HK
dc.contributor.authorZhang, CCen_HK
dc.contributor.authorLi, PBen_HK
dc.contributor.authorNie, YCen_HK
dc.contributor.authorWu, Hen_HK
dc.contributor.authorShen, JGen_HK
dc.contributor.authorSu, WWen_HK
dc.date.accessioned2012-06-22T06:35:38Z-
dc.date.available2012-06-22T06:35:38Z-
dc.date.issued2012en_HK
dc.identifier.citationInternational Immunopharmacology, 2012, v. 13 n. 3, p. 301-307en_HK
dc.identifier.issn1567-5769en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149301-
dc.description.abstractNaringin is a flavanone with various bioactivities including expectorant effect, antitussive effect and inhibitory effects on asthma and acute lung injury. In present study we examined the effects of naringin on enhanced cough, airway hyperresponsiveness (AHR) and airway inflammation in chronic cigarette smoke (CS) exposure-induced chronic bronchitis in guinea pigs. To achieve this, guinea pigs were exposed to CS for 8 weeks (10 cigarettes/day, 6 days/week). Oral administration of naringin (9.2, 18.4 and 36.8 mg/kg) significantly attenuated the enhanced cough and AHR in smoke-exposed guinea pigs, reduced the concentrations of interleukin-8 (IL-8), leukotriene B4 (LTB4) and tumor necrosis factor-α (TNF-α) in bronchoalveolar lavage fluid (BALF) and decreased the myeloperoxidase (MPO) activity in both BALF and lung tissue, but did not significantly decrease the leukocytes in BALF. Naringin also improved superoxidase dismutase (SOD) activity in lung tissue and increased the content of lipoxin A4 (LXA4) in BALF in this guinea pig model of chronic bronchitis. These results suggested that naringin exhibited antitussive, anti-AHR and anti-inflammation effects on chronic CS exposure-induced chronic bronchitis in guinea pigs, and may possess novel therapeutic potential in the treatment of chronic bronchitis. © 2012 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimpen_HK
dc.relation.ispartofInternational Immunopharmacologyen_HK
dc.subjectAirway hyperresponsivenessen_HK
dc.subjectAnti-inflammationen_HK
dc.subjectCoughen_HK
dc.subjectLipoxin A4en_HK
dc.subjectNaringinen_HK
dc.subjectSmokeen_HK
dc.titleNaringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smokeen_HK
dc.typeArticleen_HK
dc.identifier.emailShen, JG: shenjg@hku.hken_HK
dc.identifier.authorityShen, JG=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.intimp.2012.04.019en_HK
dc.identifier.pmid22575871-
dc.identifier.scopuseid_2-s2.0-84861446574en_HK
dc.identifier.hkuros200245en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861446574&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue3en_HK
dc.identifier.spage301en_HK
dc.identifier.epage307en_HK
dc.identifier.isiWOS:000306037500011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLuo, YL=37026466900en_HK
dc.identifier.scopusauthoridZhang, CC=55227164500en_HK
dc.identifier.scopusauthoridLi, PB=10141281200en_HK
dc.identifier.scopusauthoridNie, YC=53865296000en_HK
dc.identifier.scopusauthoridWu, H=24465764000en_HK
dc.identifier.scopusauthoridShen, JG=7404929947en_HK
dc.identifier.scopusauthoridSu, WW=7402010268en_HK
dc.identifier.citeulike10661717-

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