File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Large cell transformation of Sézary syndrome: A conventional and molecular cytogenetic study

TitleLarge cell transformation of Sézary syndrome: A conventional and molecular cytogenetic study
Authors
KeywordsComparative genomic hybridization
Cytogenetics
DNA ploidy
Large cell transformation
Mycosis fungoides
Polyploidy
Sézary syndrome
Issue Date2000
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 2000, v. 113 n. 6, p. 792-797 How to Cite?
AbstractHyperdiploidy sometimes is found in mycosis fungoides -Sézary syndrome, but its diagnostic significance remains undefined. We report an unusual case of Sézary syndrome manifesting with leukemic large cell transformation. Conventional karyotypic analysis showed the presence of a near-tetraploid neoplastic clone. With dual-color cytometric analysis, we showed that the large Sézary cells were near-tetraploid with a DNA index of 1.86, thereby demonstrating a direct relationship between cell size and ploidy. Comparative genomic hybridization further showed chromosomal imbalances that were not revealed on conventional karyotyping. Our findings suggest that hyperdiploidy may be a marker of large cell transformation, so that when this karyotypic abnormality is found in mycosis fungoides - Sézary syndrome, a search for such a complication is indicated.
Persistent Identifierhttp://hdl.handle.net/10722/148214
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, CCen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorSiu, LLPen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-05-29T06:11:32Z-
dc.date.available2012-05-29T06:11:32Z-
dc.date.issued2000en_HK
dc.identifier.citationAmerican Journal Of Clinical Pathology, 2000, v. 113 n. 6, p. 792-797en_HK
dc.identifier.issn0002-9173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148214-
dc.description.abstractHyperdiploidy sometimes is found in mycosis fungoides -Sézary syndrome, but its diagnostic significance remains undefined. We report an unusual case of Sézary syndrome manifesting with leukemic large cell transformation. Conventional karyotypic analysis showed the presence of a near-tetraploid neoplastic clone. With dual-color cytometric analysis, we showed that the large Sézary cells were near-tetraploid with a DNA index of 1.86, thereby demonstrating a direct relationship between cell size and ploidy. Comparative genomic hybridization further showed chromosomal imbalances that were not revealed on conventional karyotyping. Our findings suggest that hyperdiploidy may be a marker of large cell transformation, so that when this karyotypic abnormality is found in mycosis fungoides - Sézary syndrome, a search for such a complication is indicated.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_HK
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_HK
dc.subjectComparative genomic hybridizationen_HK
dc.subjectCytogeneticsen_HK
dc.subjectDNA ploidyen_HK
dc.subjectLarge cell transformationen_HK
dc.subjectMycosis fungoidesen_HK
dc.subjectPolyploidyen_HK
dc.subjectSézary syndromeen_HK
dc.subject.meshAgeden_US
dc.subject.meshCell Nucleus - Ultrastructureen_US
dc.subject.meshCell Transformation, Neoplasticen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosome Disordersen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLymphoma, Large B-Cell, Diffuse - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMycosis Fungoides - Genetics - Pathologyen_US
dc.subject.meshNeoplasms, Multiple Primary - Genetics - Pathologyen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPloidiesen_US
dc.subject.meshSezary Syndrome - Genetics - Pathologyen_US
dc.subject.meshSkin Neoplasms - Genetics - Pathologyen_US
dc.titleLarge cell transformation of Sézary syndrome: A conventional and molecular cytogenetic studyen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, CC:scc@pathology.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authoritySo, CC=rp00391en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1309/4E9V-HBY1-TMBM-K3BYen_HK
dc.identifier.pmid10874879-
dc.identifier.scopuseid_2-s2.0-0034501285en_HK
dc.identifier.hkuros49601-
dc.identifier.hkuros60369-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034501285&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume113en_HK
dc.identifier.issue6en_HK
dc.identifier.spage792en_HK
dc.identifier.epage797en_HK
dc.identifier.isiWOS:000087358900006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSo, CC=7102919978en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridSiu, LLP=35574705900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats