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Article: Ovarian mature cystic teratoma with malignant transformation: An interphase cytogenetic study

TitleOvarian mature cystic teratoma with malignant transformation: An interphase cytogenetic study
Authors
Issue Date1998
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com
Citation
International Journal Of Gynecological Pathology, 1998, v. 17 n. 4, p. 351-357 How to Cite?
AbstractThe chromosomal composition of cancers arising in ovarian mature cystic teratoma (MCT) was analyzed using chromosome in situ hybridization (CISH) performed on paraffin-embedded material from 10 squamous cell carcinomas, 1 adenocarcinoma, 1 thyroid papillary carcinoma, and 1 strumal carcinoid. Cervical tissue from seven of these patients was used as a control. In the cancers, a relative gain of chromosome 16 (in 7 cases), chromosome 12 (in 9), chromosome 11 (in 10), and chromosome X (in 8) was detected. Trisomy 12 was diagnosed in eight cases. No chromosomal aberrations were detected in the strumal carcinoid. In the benign areas of the MCTs, only one case showed a gain of chromosome 11, although, in another case, there was a gain of chromosome X. Malignant transformation of MCTs often occurs in association with complex chromosome aberrations that may play a role in the development of such carcinomas.
Persistent Identifierhttp://hdl.handle.net/10722/148103
ISSN
2015 Impact Factor: 1.437
2015 SCImago Journal Rankings: 0.723
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShen, DHen_US
dc.contributor.authorKhoo, USen_US
dc.contributor.authorXue, WCen_US
dc.contributor.authorCheung, ANYen_US
dc.date.accessioned2012-05-29T06:10:51Z-
dc.date.available2012-05-29T06:10:51Z-
dc.date.issued1998en_US
dc.identifier.citationInternational Journal Of Gynecological Pathology, 1998, v. 17 n. 4, p. 351-357en_US
dc.identifier.issn0277-1691en_US
dc.identifier.urihttp://hdl.handle.net/10722/148103-
dc.description.abstractThe chromosomal composition of cancers arising in ovarian mature cystic teratoma (MCT) was analyzed using chromosome in situ hybridization (CISH) performed on paraffin-embedded material from 10 squamous cell carcinomas, 1 adenocarcinoma, 1 thyroid papillary carcinoma, and 1 strumal carcinoid. Cervical tissue from seven of these patients was used as a control. In the cancers, a relative gain of chromosome 16 (in 7 cases), chromosome 12 (in 9), chromosome 11 (in 10), and chromosome X (in 8) was detected. Trisomy 12 was diagnosed in eight cases. No chromosomal aberrations were detected in the strumal carcinoid. In the benign areas of the MCTs, only one case showed a gain of chromosome 11, although, in another case, there was a gain of chromosome X. Malignant transformation of MCTs often occurs in association with complex chromosome aberrations that may play a role in the development of such carcinomas.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.comen_US
dc.relation.ispartofInternational Journal of Gynecological Pathologyen_US
dc.subject.meshAdenocarcinoma - Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoid Tumor - Geneticsen_US
dc.subject.meshCarcinoma, Papillary - Geneticsen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshCell Transformation, Neoplastic - Geneticsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosomes, Human, Pair 11en_US
dc.subject.meshChromosomes, Human, Pair 12en_US
dc.subject.meshChromosomes, Human, Pair 16en_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOvarian Neoplasms - Geneticsen_US
dc.subject.meshTeratoma - Geneticsen_US
dc.subject.meshThyroid Neoplasms - Geneticsen_US
dc.subject.meshX Chromosomeen_US
dc.titleOvarian mature cystic teratoma with malignant transformation: An interphase cytogenetic studyen_US
dc.typeArticleen_US
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_US
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_US
dc.identifier.authorityKhoo, US=rp00362en_US
dc.identifier.authorityCheung, ANY=rp00542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9785136en_US
dc.identifier.scopuseid_2-s2.0-0031720088en_US
dc.identifier.hkuros34219en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031720088&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.spage351en_US
dc.identifier.epage357en_US
dc.identifier.isiWOS:000076158600009-
dc.publisher.placeUnited Statesen_US

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