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Article: Structure and Biology of the Intervertebral Disk in Health and Disease

TitleStructure and Biology of the Intervertebral Disk in Health and Disease
Authors
KeywordsBiology
Degeneration
Development
Extracellular matrix
Intervertebral disk
Issue Date2011
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cort
Citation
Orthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 447-464 How to Cite?
AbstractThe intervertebral disks along the spine provide motion and protection against mechanical loading. The 3 structural components, nucleus pulposus, annulus fibrosus, and cartilage endplate, function as a synergistic unit, though each has its own role. The cells within each of these components have distinct origins in development and morphology, producing specific extracellular matrix proteins that are organized into unique architectures fit for intervertebral disk function. This article focuses on various aspects of intervertebral disk biology and disruptions that could lead to diseases such as intervertebral disk degeneration. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147640
ISSN
2015 Impact Factor: 1.51
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, WCWen_HK
dc.contributor.authorSze, KLen_HK
dc.contributor.authorSamartzis, Den_HK
dc.contributor.authorLeung, VYLen_HK
dc.contributor.authorChan, Den_HK
dc.date.accessioned2012-05-29T06:05:09Z-
dc.date.available2012-05-29T06:05:09Z-
dc.date.issued2011en_HK
dc.identifier.citationOrthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 447-464en_HK
dc.identifier.issn0030-5898en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147640-
dc.description.abstractThe intervertebral disks along the spine provide motion and protection against mechanical loading. The 3 structural components, nucleus pulposus, annulus fibrosus, and cartilage endplate, function as a synergistic unit, though each has its own role. The cells within each of these components have distinct origins in development and morphology, producing specific extracellular matrix proteins that are organized into unique architectures fit for intervertebral disk function. This article focuses on various aspects of intervertebral disk biology and disruptions that could lead to diseases such as intervertebral disk degeneration. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/corten_HK
dc.relation.ispartofOrthopedic Clinics of North Americaen_HK
dc.subjectBiologyen_HK
dc.subjectDegenerationen_HK
dc.subjectDevelopmenten_HK
dc.subjectExtracellular matrixen_HK
dc.subjectIntervertebral disken_HK
dc.subject.meshCervical Vertebraeen_US
dc.subject.meshCytokines - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntervertebral Disc - Anatomy & Histology - Embryology - Physiologyen_US
dc.subject.meshIntervertebral Disc Degeneration - Physiopathologyen_US
dc.subject.meshLow Back Pain - Etiology - Physiopathologyen_US
dc.subject.meshLumbar Vertebraeen_US
dc.subject.meshMaleen_US
dc.subject.meshMatrix Metalloproteinases - Metabolismen_US
dc.subject.meshThoracic Vertebraeen_US
dc.titleStructure and Biology of the Intervertebral Disk in Health and Diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailSamartzis, D: dspine@hku.hken_HK
dc.identifier.emailLeung, VYL: vicleung@hku.hken_HK
dc.identifier.emailChan, D: chand@hkucc.hku.hken_HK
dc.identifier.authoritySamartzis, D=rp01430en_HK
dc.identifier.authorityLeung, VYL=rp01764en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ocl.2011.07.012en_HK
dc.identifier.pmid21944583-
dc.identifier.scopuseid_2-s2.0-80053178250en_HK
dc.identifier.hkuros189124-
dc.identifier.hkuros210477-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053178250&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue4en_HK
dc.identifier.spage447en_HK
dc.identifier.epage464en_HK
dc.identifier.isiWOS:000208681100002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, WCW=24545687600en_HK
dc.identifier.scopusauthoridSze, KL=12779346400en_HK
dc.identifier.scopusauthoridSamartzis, D=34572771100en_HK
dc.identifier.scopusauthoridLeung, VYL=35337438900en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK

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