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Article: Tamponade properties of double-filling with perfluorohexyloctane and silicone oil in a model eye chamber

TitleTamponade properties of double-filling with perfluorohexyloctane and silicone oil in a model eye chamber
Authors
Issue Date2004
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm
Citation
Graefe's Archive For Clinical And Experimental Ophthalmology, 2004, v. 242 n. 3, p. 250-254 How to Cite?
AbstractBackground: The use of perfluoroexyloctane as a heavier-than-water tamponade for long-term use is limited by its tendency to dispersion and associated intraocular inflammation. Double-filling with silicone oil and F6H8 produces a united, two-layer bubble, appearing as a single bubble. This has been proposed as a method of improving the utility of F6H8 as a tamponade. Methods: A surface modified polymethylmethacrylate model eye chamber was double-filled with perfluorohexyloctane and silicone oil to approximate a 90% fill. The proportion of silicone oil was increased in a stepwise fashion. A qualitative comparison of surface contact at each stage was made. Chambers with one, two or no indent were used. Dispersion by agitation of the chamber was assessed. Results: With less than 20% silicone oil it was difficult to force the two liquids to make contact. With more oil they united in the form of a single bubble joined at an interface. Once joined, the sides of the single bubble were drawn away from the wall of the chamber. As the proportion of silicone oil increased the area of lost contact increased and progressed inferiorly. Compared to F6H8 alone the double-fill reduced dispersion. Conclusion: Silicone oil and F6H8 can unite to form a single bubble that changes the effectiveness of either tamponade agent on their own. The double-fill needs to have enough silicone oil to form a single bubble, but this needs to be kept as low as possible to avoid progressive loss of lateral tamponade. It does not provide good simultaneous superior and inferior tamponade. The double-fill reduces dispersion. © Springer-Verlag 2003.
Persistent Identifierhttp://hdl.handle.net/10722/146283
ISSN
2015 Impact Factor: 1.991
2015 SCImago Journal Rankings: 1.217
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHerbert, Een_HK
dc.contributor.authorStappler, Ten_HK
dc.contributor.authorWetterqvist, Cen_HK
dc.contributor.authorWilliams, Ren_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:49:56Z-
dc.date.available2012-04-10T01:49:56Z-
dc.date.issued2004en_HK
dc.identifier.citationGraefe's Archive For Clinical And Experimental Ophthalmology, 2004, v. 242 n. 3, p. 250-254en_HK
dc.identifier.issn0721-832Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/146283-
dc.description.abstractBackground: The use of perfluoroexyloctane as a heavier-than-water tamponade for long-term use is limited by its tendency to dispersion and associated intraocular inflammation. Double-filling with silicone oil and F6H8 produces a united, two-layer bubble, appearing as a single bubble. This has been proposed as a method of improving the utility of F6H8 as a tamponade. Methods: A surface modified polymethylmethacrylate model eye chamber was double-filled with perfluorohexyloctane and silicone oil to approximate a 90% fill. The proportion of silicone oil was increased in a stepwise fashion. A qualitative comparison of surface contact at each stage was made. Chambers with one, two or no indent were used. Dispersion by agitation of the chamber was assessed. Results: With less than 20% silicone oil it was difficult to force the two liquids to make contact. With more oil they united in the form of a single bubble joined at an interface. Once joined, the sides of the single bubble were drawn away from the wall of the chamber. As the proportion of silicone oil increased the area of lost contact increased and progressed inferiorly. Compared to F6H8 alone the double-fill reduced dispersion. Conclusion: Silicone oil and F6H8 can unite to form a single bubble that changes the effectiveness of either tamponade agent on their own. The double-fill needs to have enough silicone oil to form a single bubble, but this needs to be kept as low as possible to avoid progressive loss of lateral tamponade. It does not provide good simultaneous superior and inferior tamponade. The double-fill reduces dispersion. © Springer-Verlag 2003.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htmen_HK
dc.relation.ispartofGraefe's Archive for Clinical and Experimental Ophthalmologyen_HK
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFluorocarbons - Chemistry - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshRetinal Detachment - Drug Therapy - Surgeryen_US
dc.subject.meshSilicone Oils - Chemistry - Therapeutic Useen_US
dc.subject.meshVitrectomyen_US
dc.titleTamponade properties of double-filling with perfluorohexyloctane and silicone oil in a model eye chamberen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00417-003-0830-6en_HK
dc.identifier.pmid14685875-
dc.identifier.scopuseid_2-s2.0-1842627632en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842627632&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume242en_HK
dc.identifier.issue3en_HK
dc.identifier.spage250en_HK
dc.identifier.epage254en_HK
dc.identifier.isiWOS:000220563200010-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridHerbert, E=7006358782en_HK
dc.identifier.scopusauthoridStappler, T=8563727800en_HK
dc.identifier.scopusauthoridWetterqvist, C=6507709342en_HK
dc.identifier.scopusauthoridWilliams, R=10042153900en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

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