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Book: Tumor Suppressor Genes

TitleTumor Suppressor Genes
Editors
Editor(s):Cheng, Y
KeywordsOncology
Issue Date2012
PublisherInTech
Citation
Cheng, Y. In Yue Cheng (Ed.), Tumor Suppressor Genes. Rijeka, Croatia: InTech. 2012 How to Cite?
AbstractFunctional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies.
Persistent Identifierhttp://hdl.handle.net/10722/144765
ISBN

 

DC FieldValueLanguage
dc.contributor.editorCheng, Y-
dc.date.accessioned2012-02-06T01:22:50Z-
dc.date.available2012-02-06T01:22:50Z-
dc.date.issued2012-
dc.identifier.citationCheng, Y. In Yue Cheng (Ed.), Tumor Suppressor Genes. Rijeka, Croatia: InTech. 2012-
dc.identifier.isbn9789533078793-
dc.identifier.urihttp://hdl.handle.net/10722/144765-
dc.description.abstractFunctional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies.-
dc.languageeng-
dc.publisherInTech-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectOncology-
dc.titleTumor Suppressor Genesen_US
dc.typeBooken_US
dc.identifier.emailCheng, Y: yuecheng@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5772/1337-
dc.identifier.hkuros185867-
dc.identifier.epage332 pages-
dc.publisher.placeRijeka, Croatia-

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