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Article: Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree

TitleGenetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree
Authors
KeywordsGenetic variation
Paraoxonase-2
Plasma lipoprotein
Issue Date1998
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGE
Citation
Clinical Genetics, 1998, v. 54 n. 5, p. 394-399 How to Cite?
AbstractWe report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/143118
ISSN
2014 Impact Factor: 3.931
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHegele, RAen_HK
dc.contributor.authorHarris, SBen_HK
dc.contributor.authorConnelly, PWen_HK
dc.contributor.authorHanley, AJGen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorZinman, Ben_HK
dc.contributor.authorScherer, SWen_HK
dc.date.accessioned2011-11-01T07:13:09Z-
dc.date.available2011-11-01T07:13:09Z-
dc.date.issued1998en_HK
dc.identifier.citationClinical Genetics, 1998, v. 54 n. 5, p. 394-399en_HK
dc.identifier.issn0009-9163en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143118-
dc.description.abstractWe report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.en_HK
dc.languageeng-
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGEen_HK
dc.relation.ispartofClinical Geneticsen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectGenetic variationen_HK
dc.subjectParaoxonase-2en_HK
dc.subjectPlasma lipoproteinen_HK
dc.subject.meshAryldialkylphosphatase-
dc.subject.meshEsterases - genetics-
dc.subject.meshGenetic Variation-
dc.subject.meshIndians, North American - genetics-
dc.subject.meshLipoproteins - blood-
dc.titleGenetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Creeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-9163&volume=54&issue=5&spage=394&epage=399&date=1998&atitle=Genetic+variation+in+paraoxonase-2+is+associated+with+variation+in+plasma+lipoproteins+in+Canadian+Oji-Cree-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1399-0004.1998.tb03752.x-
dc.identifier.pmid9842991en_HK
dc.identifier.scopuseid_2-s2.0-0031740464en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031740464&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue5en_HK
dc.identifier.spage394en_HK
dc.identifier.epage399en_HK
dc.identifier.isiWOS:000076952900003-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridHegele, RA=35399481100en_HK
dc.identifier.scopusauthoridHarris, SB=35500171900en_HK
dc.identifier.scopusauthoridConnelly, PW=16738577100en_HK
dc.identifier.scopusauthoridHanley, AJG=7005599486en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridZinman, B=7102090193en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK

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