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Article: Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree
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TitleGenetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree
 
AuthorsHegele, RA3 2
Harris, SB3
Connelly, PW1
Hanley, AJG4
Tsui, LC5
Zinman, B4
Scherer, SW5
 
KeywordsGenetic variation
Paraoxonase-2
Plasma lipoprotein
 
Issue Date1998
 
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGE
 
CitationClinical Genetics, 1998, v. 54 n. 5, p. 394-399 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-0004.1998.tb03752.x
 
AbstractWe report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.
 
ISSN0009-9163
2012 Impact Factor: 3.944
2012 SCImago Journal Rankings: 1.300
 
DOIhttp://dx.doi.org/10.1111/j.1399-0004.1998.tb03752.x
 
ISI Accession Number IDWOS:000076952900003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHegele, RA
 
dc.contributor.authorHarris, SB
 
dc.contributor.authorConnelly, PW
 
dc.contributor.authorHanley, AJG
 
dc.contributor.authorTsui, LC
 
dc.contributor.authorZinman, B
 
dc.contributor.authorScherer, SW
 
dc.date.accessioned2011-11-01T07:13:09Z
 
dc.date.available2011-11-01T07:13:09Z
 
dc.date.issued1998
 
dc.description.abstractWe report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinical Genetics, 1998, v. 54 n. 5, p. 394-399 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-0004.1998.tb03752.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1399-0004.1998.tb03752.x
 
dc.identifier.epage399
 
dc.identifier.isiWOS:000076952900003
 
dc.identifier.issn0009-9163
2012 Impact Factor: 3.944
2012 SCImago Journal Rankings: 1.300
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid9842991
 
dc.identifier.scopuseid_2-s2.0-0031740464
 
dc.identifier.spage394
 
dc.identifier.urihttp://hdl.handle.net/10722/143118
 
dc.identifier.volume54
 
dc.languageeng
 
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGE
 
dc.publisher.placeDenmark
 
dc.relation.ispartofClinical Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www.blackwell-synergy.com
 
dc.subject.meshAryldialkylphosphatase
 
dc.subject.meshEsterases - genetics
 
dc.subject.meshGenetic Variation
 
dc.subject.meshIndians, North American - genetics
 
dc.subject.meshLipoproteins - blood
 
dc.subjectGenetic variation
 
dc.subjectParaoxonase-2
 
dc.subjectPlasma lipoprotein
 
dc.titleGenetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree
 
dc.typeArticle
 
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<contributor.author>Tsui, LC</contributor.author>
<contributor.author>Zinman, B</contributor.author>
<contributor.author>Scherer, SW</contributor.author>
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Author Affiliations
  1. Saint Michael's Hospital University of Toronto
  2. Robarts Research Institute
  3. Western University
  4. University of Toronto
  5. Hospital for Sick Children University of Toronto