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Article: Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree

TitleGenetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree
Authors
KeywordsGenetic variation
Paraoxonase-2
Plasma lipoprotein
Issue Date1998
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGE
Citation
Clinical Genetics, 1998, v. 54 n. 5, p. 394-399 How to Cite?
Abstract
We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/143118
ISSN
2013 Impact Factor: 3.652
ISI Accession Number ID
References

 

Author Affiliations
  1. Saint Michael's Hospital University of Toronto
  2. Robarts Research Institute
  3. Western University
  4. University of Toronto
  5. Hospital for Sick Children University of Toronto
DC FieldValueLanguage
dc.contributor.authorHegele, RAen_HK
dc.contributor.authorHarris, SBen_HK
dc.contributor.authorConnelly, PWen_HK
dc.contributor.authorHanley, AJGen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorZinman, Ben_HK
dc.contributor.authorScherer, SWen_HK
dc.date.accessioned2011-11-01T07:13:09Z-
dc.date.available2011-11-01T07:13:09Z-
dc.date.issued1998en_HK
dc.identifier.citationClinical Genetics, 1998, v. 54 n. 5, p. 394-399en_HK
dc.identifier.issn0009-9163en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143118-
dc.description.abstractWe report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.en_HK
dc.languageeng-
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGEen_HK
dc.relation.ispartofClinical Geneticsen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectGenetic variationen_HK
dc.subjectParaoxonase-2en_HK
dc.subjectPlasma lipoproteinen_HK
dc.subject.meshAryldialkylphosphatase-
dc.subject.meshEsterases - genetics-
dc.subject.meshGenetic Variation-
dc.subject.meshIndians, North American - genetics-
dc.subject.meshLipoproteins - blood-
dc.titleGenetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Creeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-9163&volume=54&issue=5&spage=394&epage=399&date=1998&atitle=Genetic+variation+in+paraoxonase-2+is+associated+with+variation+in+plasma+lipoproteins+in+Canadian+Oji-Cree-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1399-0004.1998.tb03752.x-
dc.identifier.pmid9842991en_HK
dc.identifier.scopuseid_2-s2.0-0031740464en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031740464&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue5en_HK
dc.identifier.spage394en_HK
dc.identifier.epage399en_HK
dc.identifier.isiWOS:000076952900003-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridHegele, RA=35399481100en_HK
dc.identifier.scopusauthoridHarris, SB=35500171900en_HK
dc.identifier.scopusauthoridConnelly, PW=16738577100en_HK
dc.identifier.scopusauthoridHanley, AJG=7005599486en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridZinman, B=7102090193en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK

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