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Article: Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice

TitleTransplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice
Authors
Keywordshigh-mobility group box 1
lupus nephritis
monocyte chemotactic protein-1
regulatory T cell
systemic lupus erythematosus
umbilical cord mesenchymal stem cell
Issue Date2010
PublisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com
Citation
Lupus, 2010, v. 19 n. 13, p. 1502-1514 How to Cite?
AbstractSystemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. This study found that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has the same therapeutic effect as transplantation of bone marrow mesenchymal stem cells (BM-MSCs), which has been reported to be efficient in treating SLE-related symptoms in MRL/lpr mice. Multi-treatment (at the 18th, 19th, and 20th weeks of age) of 1 - 10 6 UC-MSCs was able to decrease the levels of 24-h proteinuria, serum creatinine, and anti-double-stranded DNA (dsDNA) antibody, and the extent of renal injury such as crescent formation in MRL/lpr mice. A lower, but still significant, reduction in these parameters was also observed in mice receiving a single dose of UC-MSCs (at the 18th week). UC-MSCs treatment also inhibited expression of monocyte chemotactic protein-1 (MCP-1) and high-mobility group box 1 (HMGB-1) expression in a similar fashion. UC-MSCs labeled with carboxyfluorescein diacetate succinimidyl ester (CFSE) were found in the lungs and kidneys 1 week post infusion. In addition, after 11 weeks post UC-MSCs infusion, human cells were found in kidney of UC-MSCs-treated mice. These findings indicated that UC-MSCs transplantation might be a potentially promising approach in the treatment of lupus nephritis, possibly by inhibiting MCP-1 and HMGB-1 production. Lupus (2010) 19, 1502-1514. © The Author(s), 2010.
Persistent Identifierhttp://hdl.handle.net/10722/137628
ISSN
2015 Impact Factor: 2.118
2015 SCImago Journal Rankings: 0.878
ISI Accession Number ID
Funding AgencyGrant Number
Chinese National Natural Science Foundation30772014
30972736
Chinese National 115 Supporting Program2008BAI59B02
Jiangsu Province 135 Talent FoundationRC2007002
Jiangsu Province Natural Science Foundation09KJB320010
Funding Information:

This work was supported by grants from Chinese National Natural Science Foundation [No. 30772014, No. 30972736]; Chinese National 115 Supporting Program [2008BAI59B02]; The Jiangsu Province 135 Talent Foundation [RC2007002]; Jiangsu Province Natural Science Foundation [No. 09KJB320010].

References

 

DC FieldValueLanguage
dc.contributor.authorGu, Zen_HK
dc.contributor.authorAkiyama, Ken_HK
dc.contributor.authorMa, Xen_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorFeng, Xen_HK
dc.contributor.authorYao, Gen_HK
dc.contributor.authorHou, Yen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorGilkeson, GSen_HK
dc.contributor.authorSilver, RMen_HK
dc.contributor.authorZeng, Xen_HK
dc.contributor.authorShi, Sen_HK
dc.contributor.authorSun, Len_HK
dc.date.accessioned2011-08-26T14:29:42Z-
dc.date.available2011-08-26T14:29:42Z-
dc.date.issued2010en_HK
dc.identifier.citationLupus, 2010, v. 19 n. 13, p. 1502-1514en_HK
dc.identifier.issn0961-2033en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137628-
dc.description.abstractSystemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. This study found that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has the same therapeutic effect as transplantation of bone marrow mesenchymal stem cells (BM-MSCs), which has been reported to be efficient in treating SLE-related symptoms in MRL/lpr mice. Multi-treatment (at the 18th, 19th, and 20th weeks of age) of 1 - 10 6 UC-MSCs was able to decrease the levels of 24-h proteinuria, serum creatinine, and anti-double-stranded DNA (dsDNA) antibody, and the extent of renal injury such as crescent formation in MRL/lpr mice. A lower, but still significant, reduction in these parameters was also observed in mice receiving a single dose of UC-MSCs (at the 18th week). UC-MSCs treatment also inhibited expression of monocyte chemotactic protein-1 (MCP-1) and high-mobility group box 1 (HMGB-1) expression in a similar fashion. UC-MSCs labeled with carboxyfluorescein diacetate succinimidyl ester (CFSE) were found in the lungs and kidneys 1 week post infusion. In addition, after 11 weeks post UC-MSCs infusion, human cells were found in kidney of UC-MSCs-treated mice. These findings indicated that UC-MSCs transplantation might be a potentially promising approach in the treatment of lupus nephritis, possibly by inhibiting MCP-1 and HMGB-1 production. Lupus (2010) 19, 1502-1514. © The Author(s), 2010.en_HK
dc.languageengen_US
dc.publisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.comen_HK
dc.relation.ispartofLupusen_HK
dc.rightsLupus. Copyright © Sage Publications Ltd.-
dc.subjecthigh-mobility group box 1en_HK
dc.subjectlupus nephritisen_HK
dc.subjectmonocyte chemotactic protein-1en_HK
dc.subjectregulatory T cellen_HK
dc.subjectsystemic lupus erythematosusen_HK
dc.subjectumbilical cord mesenchymal stem cellen_HK
dc.subject.meshAntibodies, Antinuclear - metabolism-
dc.subject.meshBone Marrow Cells - metabolism-
dc.subject.meshLupus Nephritis - pathology - therapy-
dc.subject.meshMesenchymal Stem Cell Transplantation - methods-
dc.subject.meshUmbilical Cord - cytology-
dc.titleTransplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0961-2033&volume=19&issue=13&spage=1502&epage=1514&date=2010&atitle=Transplantation+of+umbilical+cord+mesenchymal+stem+cells+alleviates+lupus+nephritis+in+MRL/lpr+mice-
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0961203310373782en_HK
dc.identifier.pmid20647254-
dc.identifier.scopuseid_2-s2.0-78649245336en_HK
dc.identifier.hkuros191297en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649245336&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue13en_HK
dc.identifier.spage1502en_HK
dc.identifier.epage1514en_HK
dc.identifier.isiWOS:000283379000003-
dc.publisher.placeUnited Kingdomen_HK

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