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Article: The patch-clamp and planar lipid bilayer techniques: Powerful and versatile tools to investigate the CFTR Cl- channel

TitleThe patch-clamp and planar lipid bilayer techniques: Powerful and versatile tools to investigate the CFTR Cl- channel
Authors
KeywordsAnion permeation
Channel gating
Channel regulation
Chloride channel activity
Single-channel recording
Whole-cell recording
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcf
Citation
Journal Of Cystic Fibrosis, 2004, v. 3 SUPPL. 2, p. 101-108 How to Cite?
AbstractUsing the patch-clamp (PC) and planar lipid bilayer (PLB) techniques the molecular behaviour of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel can be visualised in real-time. The PC technique is a highly powerful and versatile method to investigate CFTR's mechanism of action, interaction with other proteins and physiological role. Using the PLB technique, the structure and function of CFTR can be investigated free from the influence of other proteins. Here we discuss how these techniques are employed to investigate the CFTR Cl- channel with special emphasis on its permeation, conduction and gating properties. © 2004 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/137018
ISSN
2015 Impact Factor: 3.853
2015 SCImago Journal Rankings: 1.486
References

 

DC FieldValueLanguage
dc.contributor.authorSheppard, DNen_HK
dc.contributor.authorGray, MAen_HK
dc.contributor.authorGong, Xen_HK
dc.contributor.authorSohma, Yen_HK
dc.contributor.authorKogan, Ien_HK
dc.contributor.authorBenos, DJen_HK
dc.contributor.authorScottWard, TSen_HK
dc.contributor.authorChen, JHen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorCai, Zen_HK
dc.contributor.authorGupta, Jen_HK
dc.contributor.authorLi, Cen_HK
dc.contributor.authorRamjeesingh, Men_HK
dc.contributor.authorBerdiev, BKen_HK
dc.contributor.authorIsmailov, IIen_HK
dc.contributor.authorBear, CEen_HK
dc.contributor.authorHwang, TCen_HK
dc.contributor.authorLinsdell, Pen_HK
dc.contributor.authorHug, MJen_HK
dc.date.accessioned2011-07-29T02:14:22Z-
dc.date.available2011-07-29T02:14:22Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Cystic Fibrosis, 2004, v. 3 SUPPL. 2, p. 101-108en_HK
dc.identifier.issn1569-1993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137018-
dc.description.abstractUsing the patch-clamp (PC) and planar lipid bilayer (PLB) techniques the molecular behaviour of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel can be visualised in real-time. The PC technique is a highly powerful and versatile method to investigate CFTR's mechanism of action, interaction with other proteins and physiological role. Using the PLB technique, the structure and function of CFTR can be investigated free from the influence of other proteins. Here we discuss how these techniques are employed to investigate the CFTR Cl- channel with special emphasis on its permeation, conduction and gating properties. © 2004 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcfen_HK
dc.relation.ispartofJournal of Cystic Fibrosisen_HK
dc.subjectAnion permeationen_HK
dc.subjectChannel gatingen_HK
dc.subjectChannel regulationen_HK
dc.subjectChloride channel activityen_HK
dc.subjectSingle-channel recordingen_HK
dc.subjectWhole-cell recordingen_HK
dc.titleThe patch-clamp and planar lipid bilayer techniques: Powerful and versatile tools to investigate the CFTR Cl- channelen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, JH: jhlchen@hku.hken_HK
dc.identifier.authorityChen, JH=rp01518en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jcf.2004.05.046en_HK
dc.identifier.pmid15463939-
dc.identifier.scopuseid_2-s2.0-19944414292en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19944414292&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issueSUPPL. 2en_HK
dc.identifier.spage101en_HK
dc.identifier.epage108en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridSheppard, DN=7201812458en_HK
dc.identifier.scopusauthoridGray, MA=7401585136en_HK
dc.identifier.scopusauthoridGong, X=7201999007en_HK
dc.identifier.scopusauthoridSohma, Y=7004865261en_HK
dc.identifier.scopusauthoridKogan, I=7102422686en_HK
dc.identifier.scopusauthoridBenos, DJ=7101816769en_HK
dc.identifier.scopusauthoridScottWard, TS=6506239769en_HK
dc.identifier.scopusauthoridChen, JH=7501878156en_HK
dc.identifier.scopusauthoridLi, H=24468545300en_HK
dc.identifier.scopusauthoridCai, Z=7402905250en_HK
dc.identifier.scopusauthoridGupta, J=36762073000en_HK
dc.identifier.scopusauthoridLi, C=7501673777en_HK
dc.identifier.scopusauthoridRamjeesingh, M=7003391689en_HK
dc.identifier.scopusauthoridBerdiev, BK=7004021700en_HK
dc.identifier.scopusauthoridIsmailov, II=35570991100en_HK
dc.identifier.scopusauthoridBear, CE=7006718679en_HK
dc.identifier.scopusauthoridHwang, TC=7202849062en_HK
dc.identifier.scopusauthoridLinsdell, P=7004694661en_HK
dc.identifier.scopusauthoridHug, MJ=7005762371en_HK

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