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Article: Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting down syndrome pregnancies

TitleMaternal serum anti-Mullerian hormone level is not superior to chronological age in predicting down syndrome pregnancies
Authors
KeywordsAnti-Mullerian hormone
Down syndrome
Pregnancy
Issue Date2010
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2010, v. 30 n. 4, p. 320-324 How to Cite?
AbstractObjective: To compare the difference in maternal serum anti-Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy. Method: A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay. Results: There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples. Conclusions: Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross-sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/135633
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
Funding AgencyGrant Number
Committee on Research and Conference Grants, University of Hong Kong
Funding Information:

This study was supported by a small project funding grant from the Committee on Research and Conference Grants, University of Hong Kong. The authors would like to thank Ms Benancy Wong for performing the AMH assay and Mr Victor Ng for his technical support.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, HWRen_HK
dc.contributor.authorHui, PWen_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorLau, ETKen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorHo, PCen_HK
dc.contributor.authorNg, EHYen_HK
dc.date.accessioned2011-07-27T01:38:07Z-
dc.date.available2011-07-27T01:38:07Z-
dc.date.issued2010en_HK
dc.identifier.citationPrenatal Diagnosis, 2010, v. 30 n. 4, p. 320-324en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135633-
dc.description.abstractObjective: To compare the difference in maternal serum anti-Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy. Method: A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay. Results: There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples. Conclusions: Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross-sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.-
dc.subjectAnti-Mullerian hormoneen_HK
dc.subjectDown syndromeen_HK
dc.subjectPregnancyen_HK
dc.subject.meshAnti-Mullerian Hormone - blood-
dc.subject.meshDown Syndrome - blood-
dc.subject.meshGestational Age-
dc.subject.meshMaternal Age-
dc.subject.meshPregnancy - blood-
dc.titleMaternal serum anti-Mullerian hormone level is not superior to chronological age in predicting down syndrome pregnanciesen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, HWR: raymondli@hku.hken_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.authorityLi, HWR=rp01649en_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pd.2455en_HK
dc.identifier.pmid20155783-
dc.identifier.scopuseid_2-s2.0-77950671923en_HK
dc.identifier.hkuros187015en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950671923&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue4en_HK
dc.identifier.spage320en_HK
dc.identifier.epage324en_HK
dc.identifier.isiWOS:000277629600004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, HWR=7404724295en_HK
dc.identifier.scopusauthoridHui, PW=7101621830en_HK
dc.identifier.scopusauthoridTang, MHY=8943401300en_HK
dc.identifier.scopusauthoridLau, ETK=7103086081en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK

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