Article: Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma?

File Download

No File Attached
The HKU Scholars Hub has contact details for these author(s).

Links for fulltext
(May Require Subscription)

Publisher Website: 10.1002/lt.22362
Scopus: eid_2-s2.0-80053291972
PMID: 21688383
Find via

Supplementary

Citations:
- Scopus:
- Web of Science:
- PubMed Central:
Item Statistics (The Hub)
Appears in Collections:
- Surgery: Journal/Magazine Articles

Title	Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma?
Authors	Cheung, TT1 Chan, SC1 Ho, CL2 Chok, KSH1 Chan, ACY1 Sharr, WW1 Ng, KKC1 Poon, RTP1 Lo, CM1 Fan, ST1
Keywords	Acetic acid c 11 Fluorodeoxyglucose f 18 Advanced cancer Cancer invasion Cancer recurrence
Issue Date	2011
Publisher	John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation	Liver Transplantation, 2011, v. 17 n. 10, p. 1218-1225 [How to Cite?] DOI: http://dx.doi.org/10.1002/lt.22362
Abstract	Microvascular invasion is a poor prognostic indicator of the recurrence of hepatocellular carcinoma (HCC) after surgical treatment. Positron emission tomography (PET) with [ 18F]fludeoxyglucose ([ 18F]FDG) as a tracer has been employed to predict the prognosis before surgery for various kinds of tumors, but it has not been found to be sensitive enough for HCC. Thus, [ 11C]acetate has been adopted as an additional tracer. This study was designed to evaluate the ability of dual-tracer PET ([ 18F]FDG and [ 11C]acetate) to predict microvascular invasion before liver resection or transplantation. Fifty-eight HCC patients who were preoperatively examined with whole-body dual-tracer PET were studied. Twenty-five patients were [ 18F]FDG-positive, and 56 were [ 11C]acetate-positive. The sensitivity of [ 18F]FDG in detecting primary HCC was 43%, and the sensitivity of [ 11C]acetate was 93%. Twenty-nine patients had HCC with microvascular invasion according to the final pathological examination. The sensitivity, specificity, positive predictive value, and negative predictive value of [ 18F]FDG PET in predicting microvascular invasion were 55.2%, 69%, 64%, and 60.6%, respectively; the corresponding rates for [ 11C]acetate PET were 93.1%, 0%, 48.2%, and 0%. The factors associated with HCC recurrence, which included multifocal involvement, a large tumor size, microsatellite lesions, poor HCC differentiation, and an advanced stage of disease, were analyzed and compared with positive PET results. A tumor size greater than 5 cm was significantly associated with positive [ 18F]FDG PET results; [ 11C]acetate was not associated with poor prognostic indicators. Preoperative [ 18F]FDG PET may predict microvascular invasion. The addition of [ 11C]acetate improves the overall sensitivity of PET, but it has no incremental value in predicting microvascular invasion. © 2011 AASLD.
ISSN	1527-6465 2011 Impact Factor: 3.386 2011 SCImago Journal Rankings: 0.305
DOI	http://dx.doi.org/10.1002/lt.22362
ISI Accession Number ID	WOS:000295234700013
References	References in Scopus

DC Field	Value
dc.contributor.author	Cheung, TT
dc.contributor.author	Chan, SC
dc.contributor.author	Ho, CL
dc.contributor.author	Chok, KSH
dc.contributor.author	Chan, ACY
dc.contributor.author	Sharr, WW
dc.contributor.author	Ng, KKC
dc.contributor.author	Poon, RTP
dc.contributor.author	Lo, CM
dc.contributor.author	Fan, ST
dc.date.accessioned	2011-07-27T01:36:26Z
dc.date.available	2011-07-27T01:36:26Z
dc.date.issued	2011
dc.description.abstract	Microvascular invasion is a poor prognostic indicator of the recurrence of hepatocellular carcinoma (HCC) after surgical treatment. Positron emission tomography (PET) with [ 18F]fludeoxyglucose ([ 18F]FDG) as a tracer has been employed to predict the prognosis before surgery for various kinds of tumors, but it has not been found to be sensitive enough for HCC. Thus, [ 11C]acetate has been adopted as an additional tracer. This study was designed to evaluate the ability of dual-tracer PET ([ 18F]FDG and [ 11C]acetate) to predict microvascular invasion before liver resection or transplantation. Fifty-eight HCC patients who were preoperatively examined with whole-body dual-tracer PET were studied. Twenty-five patients were [ 18F]FDG-positive, and 56 were [ 11C]acetate-positive. The sensitivity of [ 18F]FDG in detecting primary HCC was 43%, and the sensitivity of [ 11C]acetate was 93%. Twenty-nine patients had HCC with microvascular invasion according to the final pathological examination. The sensitivity, specificity, positive predictive value, and negative predictive value of [ 18F]FDG PET in predicting microvascular invasion were 55.2%, 69%, 64%, and 60.6%, respectively; the corresponding rates for [ 11C]acetate PET were 93.1%, 0%, 48.2%, and 0%. The factors associated with HCC recurrence, which included multifocal involvement, a large tumor size, microsatellite lesions, poor HCC differentiation, and an advanced stage of disease, were analyzed and compared with positive PET results. A tumor size greater than 5 cm was significantly associated with positive [ 18F]FDG PET results; [ 11C]acetate was not associated with poor prognostic indicators. Preoperative [ 18F]FDG PET may predict microvascular invasion. The addition of [ 11C]acetate improves the overall sensitivity of PET, but it has no incremental value in predicting microvascular invasion. © 2011 AASLD.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Liver Transplantation, 2011, v. 17 n. 10, p. 1218-1225 [How to Cite?] DOI: http://dx.doi.org/10.1002/lt.22362
dc.identifier.doi	http://dx.doi.org/10.1002/lt.22362
dc.identifier.epage	1225
dc.identifier.hkuros	187485
dc.identifier.isi	WOS:000295234700013
dc.identifier.issn	1527-6465 2011 Impact Factor: 3.386 2011 SCImago Journal Rankings: 0.305
dc.identifier.issue	10
dc.identifier.openurl
dc.identifier.pmid	21688383
dc.identifier.scopus	eid_2-s2.0-80053291972
dc.identifier.spage	1218
dc.identifier.uri	http://hdl.handle.net/10722/135520
dc.identifier.volume	17
dc.language	eng
dc.publisher	John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
dc.publisher.place	United States
dc.relation.ispartof	Liver Transplantation
dc.relation.references	References in Scopus
dc.rights	Liver Transplantation. Copyright © John Wiley & Sons, Inc.
dc.subject	Acetic acid c 11
dc.subject	Fluorodeoxyglucose f 18
dc.subject	Advanced cancer
dc.subject	Cancer invasion
dc.subject	Cancer recurrence
dc.title	Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma?
dc.type	Article

<?xml encoding="utf-8" version="1.0"?><item><contributor.author>Cheung, TT</contributor.author><contributor.author>Chan, SC</contributor.author><contributor.author>Ho, CL</contributor.author><contributor.author>Chok, KSH</contributor.author><contributor.author>Chan, ACY</contributor.author><contributor.author>Sharr, WW</contributor.author><contributor.author>Ng, KKC</contributor.author><contributor.author>Poon, RTP</contributor.author><contributor.author>Lo, CM</contributor.author><contributor.author>Fan, ST</contributor.author><date.accessioned>2011-07-27T01:36:26Z</date.accessioned><date.available>2011-07-27T01:36:26Z</date.available><date.issued>2011</date.issued><identifier.citation>Liver Transplantation, 2011, v. 17 n. 10, p. 1218-1225</identifier.citation><identifier.issn>1527-6465</identifier.issn><identifier.uri>http://hdl.handle.net/10722/135520</identifier.uri><description.abstract>Microvascular invasion is a poor prognostic indicator of the recurrence of hepatocellular carcinoma (HCC) after surgical treatment. Positron emission tomography (PET) with [ 18F]fludeoxyglucose ([ 18F]FDG) as a tracer has been employed to predict the prognosis before surgery for various kinds of tumors, but it has not been found to be sensitive enough for HCC. Thus, [ 11C]acetate has been adopted as an additional tracer. This study was designed to evaluate the ability of dual-tracer PET ([ 18F]FDG and [ 11C]acetate) to predict microvascular invasion before liver resection or transplantation. Fifty-eight HCC patients who were preoperatively examined with whole-body dual-tracer PET were studied. Twenty-five patients were [ 18F]FDG-positive, and 56 were [ 11C]acetate-positive. The sensitivity of [ 18F]FDG in detecting primary HCC was 43%, and the sensitivity of [ 11C]acetate was 93%. Twenty-nine patients had HCC with microvascular invasion according to the final pathological examination. The sensitivity, specificity, positive predictive value, and negative predictive value of [ 18F]FDG PET in predicting microvascular invasion were 55.2%, 69%, 64%, and 60.6%, respectively; the corresponding rates for [ 11C]acetate PET were 93.1%, 0%, 48.2%, and 0%. The factors associated with HCC recurrence, which included multifocal involvement, a large tumor size, microsatellite lesions, poor HCC differentiation, and an advanced stage of disease, were analyzed and compared with positive PET results. A tumor size greater than 5 cm was significantly associated with positive [ 18F]FDG PET results; [ 11C]acetate was not associated with poor prognostic indicators. Preoperative [ 18F]FDG PET may predict microvascular invasion. The addition of [ 11C]acetate improves the overall sensitivity of PET, but it has no incremental value in predicting microvascular invasion. &#169; 2011 AASLD.</description.abstract><language>eng</language><publisher>John Wiley &amp; Sons, Inc. The Journal&apos;s web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021</publisher><relation.ispartof>Liver Transplantation</relation.ispartof><rights>Liver Transplantation. Copyright &#169; John Wiley &amp; Sons, Inc.</rights><subject>Acetic acid c 11</subject><subject>Fluorodeoxyglucose f 18</subject><subject>Advanced cancer</subject><subject>Cancer invasion</subject><subject>Cancer recurrence</subject><title>Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma?</title><type>Article</type><identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=1527-6465&amp;volume=17&amp;issue=10&amp;spage=1218&amp;epage=1225&amp;date=2011&amp;atitle=Can+positron+emission+tomography+with+the+dual+tracers+[11C]acetate+and+[18F]fludeoxyglucose+predict+microvascular+invasion+in+hepatocellular+carcinoma?</identifier.openurl><description.nature>Link_to_subscribed_fulltext</description.nature><identifier.doi>10.1002/lt.22362</identifier.doi><identifier.pmid>21688383</identifier.pmid><identifier.scopus>eid_2-s2.0-80053291972</identifier.scopus><identifier.hkuros>187485</identifier.hkuros><relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053291972&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references><identifier.volume>17</identifier.volume><identifier.issue>10</identifier.issue><identifier.spage>1218</identifier.spage><identifier.epage>1225</identifier.epage><identifier.isi>WOS:000295234700013</identifier.isi><publisher.place>United States</publisher.place></item>

Author Affiliations

The University of Hong Kong
Hong Kong Sanatorium and Hospital

Article: Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma?

The HKU Scholars Hub has contact details for these author(s).