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Article: Magnetic resonance spectroscopy of the brain under mild hypothermia indicates changes in neuroprotection-related metabolites

TitleMagnetic resonance spectroscopy of the brain under mild hypothermia indicates changes in neuroprotection-related metabolites
Authors
KeywordsBrain
Hypothermia
Magnetic resonance spectroscopy
Mild hypothermia
MR
MRI
MRS
Neuroprotection
Temperature
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2010, v. 475 n. 3, p. 150-155 How to Cite?
AbstractBrain hypothermia has demonstrated pronounced neuroprotective effect in patients with cardiac arrest, ischemia and acute liver failure. However, its underlying neuroprotective mechanisms remain to be elucidated in order to improve therapeutic outcomes. Single voxel proton magnetic resonance spectroscopy (1H-MRS) was performed using a 7 Tesla MRI scanner on normal Sprague-Dawley rats (N=8) in the same voxel under normothermia (36.5°C) and 30min mild hypothermia (33.5°C). Levels of various brain proton metabolites were compared. The level of lactate (Lac) and myo-inositol (mI) increased in the cortex during hypothermia. In the thalamus, taurine (Tau), a cryogen in brain, increased and choline (Cho) decreased. These metabolic alterations indicated the onset of a number of neuroprotective processes that include attenuation of energy metabolism, excitotoxic pathways, brain osmolytes and thermoregulation, thus protecting neuronal cells from damage. These experimental findings demonstrated that 1H-MRS can be applied to investigate the changes of specific metabolites and corresponding neuroprotection mechanisms in vivo noninvasively, and ultimately improve our basic understanding of hypothermia and ability to optimize its therapeutic efficacy. © 2010 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/129205
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF 7793/08M
University of Hong Kong CRCG
Funding Information:

This study was supported by the Hong Kong Research Grant Council (GRF 7793/08M) and University of Hong Kong CRCG grants.

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KWYen_HK
dc.contributor.authorChow, AMen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorYang, Jen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:33:35Z-
dc.date.available2010-12-23T08:33:35Z-
dc.date.issued2010en_HK
dc.identifier.citationNeuroscience Letters, 2010, v. 475 n. 3, p. 150-155en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129205-
dc.description.abstractBrain hypothermia has demonstrated pronounced neuroprotective effect in patients with cardiac arrest, ischemia and acute liver failure. However, its underlying neuroprotective mechanisms remain to be elucidated in order to improve therapeutic outcomes. Single voxel proton magnetic resonance spectroscopy (1H-MRS) was performed using a 7 Tesla MRI scanner on normal Sprague-Dawley rats (N=8) in the same voxel under normothermia (36.5°C) and 30min mild hypothermia (33.5°C). Levels of various brain proton metabolites were compared. The level of lactate (Lac) and myo-inositol (mI) increased in the cortex during hypothermia. In the thalamus, taurine (Tau), a cryogen in brain, increased and choline (Cho) decreased. These metabolic alterations indicated the onset of a number of neuroprotective processes that include attenuation of energy metabolism, excitotoxic pathways, brain osmolytes and thermoregulation, thus protecting neuronal cells from damage. These experimental findings demonstrated that 1H-MRS can be applied to investigate the changes of specific metabolites and corresponding neuroprotection mechanisms in vivo noninvasively, and ultimately improve our basic understanding of hypothermia and ability to optimize its therapeutic efficacy. © 2010 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.subjectBrainen_HK
dc.subjectHypothermiaen_HK
dc.subjectMagnetic resonance spectroscopyen_HK
dc.subjectMild hypothermiaen_HK
dc.subjectMRen_HK
dc.subjectMRIen_HK
dc.subjectMRSen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectTemperatureen_HK
dc.titleMagnetic resonance spectroscopy of the brain under mild hypothermia indicates changes in neuroprotection-related metabolitesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=475&issue=3&spage=150&epage=155&date=2010&atitle=Magnetic+resonance+spectroscopy+of+the+brain+under+mild+hypothermia+indicates+changes+in+neuroprotection-related+metabolites-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2010.03.066en_HK
dc.identifier.pmid20362032-
dc.identifier.scopuseid_2-s2.0-77952545541en_HK
dc.identifier.hkuros177197en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952545541&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume475en_HK
dc.identifier.issue3en_HK
dc.identifier.spage150en_HK
dc.identifier.epage155en_HK
dc.identifier.isiWOS:000278169900008-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChan, KWY=35763564900en_HK
dc.identifier.scopusauthoridChow, AM=16174234200en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridYang, J=10041733800en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike6954781-

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