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Article: B-value dependence of DTI quantitation and sensitivity in detecting neural tissue changes

TitleB-value dependence of DTI quantitation and sensitivity in detecting neural tissue changes
Authors
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2010, v. 49 n. 3, p. 2366-2374 How to Cite?
AbstractRecently, remarkable success has been demonstrated in using MR diffusion tensor imaging (DTI) to characterize white matter. Water diffusion in complex biological tissue microstructure is not a free or Gaussian process but is hindered and restricted, thus contradicting the basic assumption in conventional DTI that diffusion weighted signal decays with b-value in a monoexponential manner. Nevertheless, DTI by far is still the fastest and most robust protocol in routine research and clinical settings. To assess the b-value dependence of DTI indices and evaluate their sensitivities in detecting neural tissues changes, in vivo DTI data acquired from rat brains at postnatal day 13, 21 and 120 with different b-values (0.5-2.5 ms/μm2) and 30 gradient directions were analyzed. Results showed that the mean and directional diffusivities consistently decreased with b-value in both white and gray matters. The sensitivity of axial diffusivity (λ//) in monitoring brain maturation generally decreased with b-value whereas that of radial diffusivity (λ⊥) increased. FA generally varied less with b-value but in a manner dependent of the age and tissue type. Analysis also revealed that the FA sensitivity in detecting specific tissue changes was affected by b-value. These experimental findings confirmed the crucial effect of b-value on quantitative DTI in monitoring neural tissue alterations. They suggested that the choice of b-value in conventional DTI acquisition can be optimized for detecting neural tissue changes but shall depend on the specific tissue type and its changes or pathologies targeted, and caution must be taken in interpreting DTI indices. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/129186
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7808/09M
Funding Information:

This work was supported by the Hong Kong Research Grant Council (RGC GRF HKU7808/09M).

References

 

DC FieldValueLanguage
dc.contributor.authorHui, ESen_HK
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:33:26Z-
dc.date.available2010-12-23T08:33:26Z-
dc.date.issued2010en_HK
dc.identifier.citationNeuroimage, 2010, v. 49 n. 3, p. 2366-2374en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129186-
dc.description.abstractRecently, remarkable success has been demonstrated in using MR diffusion tensor imaging (DTI) to characterize white matter. Water diffusion in complex biological tissue microstructure is not a free or Gaussian process but is hindered and restricted, thus contradicting the basic assumption in conventional DTI that diffusion weighted signal decays with b-value in a monoexponential manner. Nevertheless, DTI by far is still the fastest and most robust protocol in routine research and clinical settings. To assess the b-value dependence of DTI indices and evaluate their sensitivities in detecting neural tissues changes, in vivo DTI data acquired from rat brains at postnatal day 13, 21 and 120 with different b-values (0.5-2.5 ms/μm2) and 30 gradient directions were analyzed. Results showed that the mean and directional diffusivities consistently decreased with b-value in both white and gray matters. The sensitivity of axial diffusivity (λ//) in monitoring brain maturation generally decreased with b-value whereas that of radial diffusivity (λ⊥) increased. FA generally varied less with b-value but in a manner dependent of the age and tissue type. Analysis also revealed that the FA sensitivity in detecting specific tissue changes was affected by b-value. These experimental findings confirmed the crucial effect of b-value on quantitative DTI in monitoring neural tissue alterations. They suggested that the choice of b-value in conventional DTI acquisition can be optimized for detecting neural tissue changes but shall depend on the specific tissue type and its changes or pathologies targeted, and caution must be taken in interpreting DTI indices. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - growth & development - physiologyen_HK
dc.subject.meshDiffusion Tensor Imagingen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshRatsen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.titleB-value dependence of DTI quantitation and sensitivity in detecting neural tissue changesen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2009.10.022en_HK
dc.identifier.pmid19837181-
dc.identifier.scopuseid_2-s2.0-71849091132en_HK
dc.identifier.hkuros177188en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-71849091132&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue3en_HK
dc.identifier.spage2366en_HK
dc.identifier.epage2374en_HK
dc.identifier.isiWOS:000273626400041-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHui, ES=16175117100en_HK
dc.identifier.scopusauthoridCheung, MM=24333907800en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike6021869-

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