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Conference Paper: Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study

TitlePlasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study
Authors
KeywordsAntihypertensive agent
Oral antidiabetic agent
Pigment epithelium derived factor
Adult
Aged
Issue Date2010
PublisherThe University of Hong Kong, Li Ka Shing Faculty of Medicine. The Conference's web site is located at http://www0.hku.hk/hbha/agingsymposium2010/index.html
Citation
The 5th International Symposium on Healthy Aging: Is Aging a Disease?, Hong Kong, 6-7 March, 2010. How to Cite?
AbstractObjective: Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, is secreted from the adipose tissue and circulates at high concentrations. A recent study found that PEDF played a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Here we investigated whether circulating PEDF levels predicted the development of the metabolic syndrome (MetS) in a 10-yr prospective study. Research Design and Methods: Baseline plasma PEDF levels were measured with an ELISA in 520 nondiabetic subjects, recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. Multiple logistic regression was used to analyze whether PEDF was an independent factor related to the MetS at baseline. The role of PEDF in predicting the development of the MetS over 10 yr was analyzed using Cox regression analysis. Results: Plasma levels of PEDF were significantly higher in men than women. At baseline, sex-adjusted PEDF levels were significantly higher in subjects with MetS (P < 0.001), and the association remained significant (odds ratio: 1.17, P = 0.015), even after adjustment for covariates. Among the components of the MetS, PEDF was independently associated with hypertriglyceridemia (P = 0.026) and hypertension (P = 0.005). Of the 396 subjects without the MetS at baseline, a total of 80 had developed the MetS over 10 yr. High baseline sex-adjusted PEDF was an independent predictor of the development of the MetS in men (hazard ratio: 1.25, P = 0.034) but not in women. Conclusion: Plasma PEDF was significantly associated with the presence of the MetS and predicted the development of the MetS in Chinese men. Copyright © 2010 by The Endocrine Society.
Persistent Identifierhttp://hdl.handle.net/10722/126369

 

DC FieldValueLanguage
dc.contributor.authorChen, Cen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorLam, KSL-
dc.date.accessioned2010-10-31T12:24:44Z-
dc.date.available2010-10-31T12:24:44Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 5th International Symposium on Healthy Aging: Is Aging a Disease?, Hong Kong, 6-7 March, 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126369-
dc.description.abstractObjective: Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, is secreted from the adipose tissue and circulates at high concentrations. A recent study found that PEDF played a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Here we investigated whether circulating PEDF levels predicted the development of the metabolic syndrome (MetS) in a 10-yr prospective study. Research Design and Methods: Baseline plasma PEDF levels were measured with an ELISA in 520 nondiabetic subjects, recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. Multiple logistic regression was used to analyze whether PEDF was an independent factor related to the MetS at baseline. The role of PEDF in predicting the development of the MetS over 10 yr was analyzed using Cox regression analysis. Results: Plasma levels of PEDF were significantly higher in men than women. At baseline, sex-adjusted PEDF levels were significantly higher in subjects with MetS (P < 0.001), and the association remained significant (odds ratio: 1.17, P = 0.015), even after adjustment for covariates. Among the components of the MetS, PEDF was independently associated with hypertriglyceridemia (P = 0.026) and hypertension (P = 0.005). Of the 396 subjects without the MetS at baseline, a total of 80 had developed the MetS over 10 yr. High baseline sex-adjusted PEDF was an independent predictor of the development of the MetS in men (hazard ratio: 1.25, P = 0.034) but not in women. Conclusion: Plasma PEDF was significantly associated with the presence of the MetS and predicted the development of the MetS in Chinese men. Copyright © 2010 by The Endocrine Society.-
dc.languageengen_HK
dc.publisherThe University of Hong Kong, Li Ka Shing Faculty of Medicine. The Conference's web site is located at http://www0.hku.hk/hbha/agingsymposium2010/index.html-
dc.relation.ispartofInternational Symposium on Healthy Aging-
dc.subjectAntihypertensive agent-
dc.subjectOral antidiabetic agent-
dc.subjectPigment epithelium derived factor-
dc.subjectAdult-
dc.subjectAged-
dc.titlePlasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=95&issue=11&spage=5074&epage=5081&date=2010&atitle=Plasma+level+of+pigment+epithelium-derived+factor+is+independently+associated+with+the+development+of+the+metabolic+syndrome+in+Chinese+men:+a+10-year+prospective+study-
dc.identifier.emailChen, C: chenchengzi@gmail.comen_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailOng, KL: okl2000@hku.hken_HK
dc.identifier.emailWat, NMS: nmswat@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.hkuros179824en_HK
dc.identifier.spage5074-
dc.description.otherThe 5th International Symposium on Healthy Aging: Is Aging a Disease?, Hong Kong, 6-7 March, 2010.-

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