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Article: Natural killer cells become tolerogenic after interaction with apoptotic cells

TitleNatural killer cells become tolerogenic after interaction with apoptotic cells
Authors
KeywordsApoptosis
NK cells
Tolerance
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.de
Citation
European Journal Of Immunology, 2010, v. 40 n. 6, p. 1718-1727 How to Cite?
AbstractNK cells are effectors in innate immunity and also participate in immunoregulation through the release of TGF-β1 and lysis of activated/autoreactive T cells. Apoptotic cells (AC) have been shown to induce tolerogenic properties in innate immune cells, including macrophages and dendritic cells, but not NK cells. In this study, we demonstrated that after interaction with AC, NK cells released TGF-β1, which in turn suppressed the production of IFN-γ by NK cells upon IL-12 and IgG activation.We further identified phosphatidylserine as a potential target on AC for the NK cells, as phosphatidylserine could stimulate NK cells to release TGF-β1, which in turn suppressed CD4+ T-cell proliferation and activation. Moreover, AC-treated NK cells displayed cytotoxicity against autologous-activated CD4 + T cells by upregulating NKp46. This lysis occurred in part through the NKp46-vimentin pathway, as activated CD4+ T cells expressed vimentin on the cell surface and blocking of vimentin or NKp46, but not other NK-cell receptors, significantly suppressed the NK-cell cytotoxicity.We report here a novel interaction between NK cells and AC, resulting in the tolerogenic properties of NK cells required for immune contraction. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/125242
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 2.568
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee, Hong Kong SAR, ChinaAOE/M-12/06
Edward Sai-Kim Hotung Paediatric Education and Research Fund
Chung Ko Lee and Cheung Yuen Kan Education and Research Fund in Paediatric Immunology
The Shun Tak District Min Yuen Tong
Wong Ching Yee Memorial Postgraduate Scholarship
Mary Sun Medical Scholarship
Funding Information:

The authors thank Dr. Eddie WK Ip (Yale University, USA) for critical review of the manuscript. The study was partially supported by the Area of Excellence Scheme of the University Grants Committee, Hong Kong SAR, China (Grant AOE/M-12/06; YLL and WT), Edward Sai-Kim Hotung Paediatric Education and Research Fund (WPC and YLL), Chung Ko Lee and Cheung Yuen Kan Education and Research Fund in Paediatric Immunology (YLL), The Shun Tak District Min Yuen Tong (YLL), Wong Ching Yee Memorial Postgraduate Scholarship (WPC) and Mary Sun Medical Scholarship (WPC).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChong, WPen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorLaw, HKWen_HK
dc.contributor.authorTu, Wen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-10-31T11:19:31Z-
dc.date.available2010-10-31T11:19:31Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropean Journal Of Immunology, 2010, v. 40 n. 6, p. 1718-1727en_HK
dc.identifier.issn0014-2980en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125242-
dc.description.abstractNK cells are effectors in innate immunity and also participate in immunoregulation through the release of TGF-β1 and lysis of activated/autoreactive T cells. Apoptotic cells (AC) have been shown to induce tolerogenic properties in innate immune cells, including macrophages and dendritic cells, but not NK cells. In this study, we demonstrated that after interaction with AC, NK cells released TGF-β1, which in turn suppressed the production of IFN-γ by NK cells upon IL-12 and IgG activation.We further identified phosphatidylserine as a potential target on AC for the NK cells, as phosphatidylserine could stimulate NK cells to release TGF-β1, which in turn suppressed CD4+ T-cell proliferation and activation. Moreover, AC-treated NK cells displayed cytotoxicity against autologous-activated CD4 + T cells by upregulating NKp46. This lysis occurred in part through the NKp46-vimentin pathway, as activated CD4+ T cells expressed vimentin on the cell surface and blocking of vimentin or NKp46, but not other NK-cell receptors, significantly suppressed the NK-cell cytotoxicity.We report here a novel interaction between NK cells and AC, resulting in the tolerogenic properties of NK cells required for immune contraction. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.deen_HK
dc.relation.ispartofEuropean Journal of Immunologyen_HK
dc.rightsPublished in European Journal of Immunology, 2010, v. 40 n. 6, p. 1718-1727-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectApoptosisen_HK
dc.subjectNK cellsen_HK
dc.subjectToleranceen_HK
dc.subject.meshApoptosis - immunology-
dc.subject.meshCytotoxicity, Immunologic - immunology-
dc.subject.meshImmune Tolerance - immunology-
dc.subject.meshKiller Cells, Natural - immunology-
dc.subject.meshSignal Transduction - immunology-
dc.titleNatural killer cells become tolerogenic after interaction with apoptotic cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2980&volume=40&issue=6&spage=1718&epage=1727&date=2010&atitle=Natural+killer+cells+become+tolerogenic+after+interaction+with+apoptotic+cells-
dc.identifier.emailTu, W:wwtu@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityTu, W=rp00416en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1002/eji.200939768en_HK
dc.identifier.pmid20391434-
dc.identifier.scopuseid_2-s2.0-77953317694en_HK
dc.identifier.hkuros179355en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953317694&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1718en_HK
dc.identifier.epage1727en_HK
dc.identifier.isiWOS:000279077200020-
dc.publisher.placeGermanyen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridChong, WP=8634104400en_HK
dc.identifier.scopusauthoridZhou, J=34871165300en_HK
dc.identifier.scopusauthoridLaw, HKW=7101939394en_HK
dc.identifier.scopusauthoridTu, W=7006479236en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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