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Article: A novel H1N1 virus causes the first pandemic of the 21st century

TitleA novel H1N1 virus causes the first pandemic of the 21st century
Authors
KeywordsH1N1
Immunology
Influenza
Pandemic
Pathogenesis
Issue Date2009
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.de
Citation
European Journal Of Immunology, 2009, v. 39 n. 11, p. 2946-2954 How to Cite?
AbstractA novel H1N1 virus of swine origin (H1N1v) is currently spreading in humans, giving rise to the first pandemic in 40 years. The disease is of moderate severity but has notable differences from seasonal influenza. In contrast to seasonal influenza, those over 60 years are relatively spared, a likely consequence of the presence of H1N1v cross-neutralizing antibody in this age group. Most patients appear to have mild influenza-like illness and many of the complications leading to hospitalization and mortality occur in those with underlying disease conditions or pregnancy. Studies in animal models suggest that the novel H1N1v pandemic virus causes a more severe illness and appears to have a greater predilection for the alveolar epithelium than seasonal influenza viruses. As there are as yet little data on the pathogenesis and immunology of H1N1v infection in humans, we have reviewed relevant data from past pandemics, from seasonal influenza and avian influenza H5N1 to highlight key issues pertaining to pathogenesis and immunology. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/125222
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 2.568
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health (NIAID)HHSN26620070005C
University Grants CommitteeAoE/M-12/06
Research Grants Council of the Hong Kong Special Administrative RegionHKU1/05C
Funding Information:

The authors acknowledge research funding from the National Institutes of Health (NIAID Contract HHSN26620070005C), the Area of Excellence Scheme of the University Grants Committee (Grant AoE/M-12/06) and the Central Allocation Grant HKU1/05C from the Research Grants Council of the Hong Kong Special Administrative Region.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorTu, WWen_HK
dc.contributor.authorYen, HLen_HK
dc.date.accessioned2010-10-31T11:18:24Z-
dc.date.available2010-10-31T11:18:24Z-
dc.date.issued2009en_HK
dc.identifier.citationEuropean Journal Of Immunology, 2009, v. 39 n. 11, p. 2946-2954en_HK
dc.identifier.issn0014-2980en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125222-
dc.description.abstractA novel H1N1 virus of swine origin (H1N1v) is currently spreading in humans, giving rise to the first pandemic in 40 years. The disease is of moderate severity but has notable differences from seasonal influenza. In contrast to seasonal influenza, those over 60 years are relatively spared, a likely consequence of the presence of H1N1v cross-neutralizing antibody in this age group. Most patients appear to have mild influenza-like illness and many of the complications leading to hospitalization and mortality occur in those with underlying disease conditions or pregnancy. Studies in animal models suggest that the novel H1N1v pandemic virus causes a more severe illness and appears to have a greater predilection for the alveolar epithelium than seasonal influenza viruses. As there are as yet little data on the pathogenesis and immunology of H1N1v infection in humans, we have reviewed relevant data from past pandemics, from seasonal influenza and avian influenza H5N1 to highlight key issues pertaining to pathogenesis and immunology. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.deen_HK
dc.relation.ispartofEuropean Journal of Immunologyen_HK
dc.rightsBefore publication use: 'Submitted to/accepted for publication in (journal) (year) WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim'. After publication use: 'Published in (full citation)'-
dc.subjectH1N1en_HK
dc.subjectImmunologyen_HK
dc.subjectInfluenzaen_HK
dc.subjectPandemicen_HK
dc.subjectPathogenesisen_HK
dc.subject.meshDisease Outbreaks - history-
dc.subject.meshHistory, 20th Century-
dc.subject.meshHistory, 21st Century-
dc.subject.meshInfluenza, Human - epidemiology - immunology - physiopathology-
dc.titleA novel H1N1 virus causes the first pandemic of the 21st centuryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2980&volume=39&issue=11&spage=2946&epage=2954&date=2009&atitle=A+novel+H1N1+virus+causes+the+first+pandemic+of+the+21st+centuryen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailTu, WW: wwtu@hku.hken_HK
dc.identifier.emailYen, HL: hyen@hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityTu, WW=rp00416en_HK
dc.identifier.authorityYen, HL=rp00304en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/eji.200939911en_HK
dc.identifier.pmid19790188-
dc.identifier.scopuseid_2-s2.0-70449419666en_HK
dc.identifier.hkuros179384en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70449419666&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2946en_HK
dc.identifier.epage2954en_HK
dc.identifier.isiWOS:000272126100002-
dc.publisher.placeGermanyen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridTu, WW=7006479236en_HK
dc.identifier.scopusauthoridYen, HL=7102476668en_HK

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