File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Strontium borate glass: Potential biomaterial for bone regeneration

TitleStrontium borate glass: Potential biomaterial for bone regeneration
Authors
KeywordsBone regeneration
Borate glass
Cytotoxicity
Strontium
Issue Date2010
PublisherThe Royal Society. The Journal's web site is located at http://publishing.royalsociety.org/index.cfm?page=1572
Citation
Journal Of The Royal Society Interface, 2010, v. 7 n. 48, p. 1025-1031 How to Cite?
AbstractBoron plays important roles in many life processes including embryogenesis, bone growth and maintenance, immune function and psychomotor skills. Thus, the delivery of boron by the degradation of borate glass is of special interest in biomedical applications. However, the cytotoxicity of borate glass which arises with the rapid release of boron has to be carefully considered. In this study, it was found that the incorporation of strontium into borate glass can not only moderate the rapid release of boron, but also induce the adhesion of osteoblast-like cells, SaOS-2, thus significantly increasing the cyto-compatibility of borate glass. The formation of multilayers of apatite with porous structure indicates that complete degradation is optimistic, and the spread of SaOS-2 covered by apatite to form a sandwich structure may induce bone-like tissue formation at earlier stages. Therefore, such novel strontium-incorporated borosilicate may act as a new generation of biomaterial for bone regeneration, which not only renders boron as a nutritious element for bone health, but also delivers strontium to stimulate formation of new bones. © 2009 The Royal Society.
Persistent Identifierhttp://hdl.handle.net/10722/125181
ISSN
2015 Impact Factor: 3.818
2015 SCImago Journal Rankings: 1.622
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Shanghai Committee of Science and Technology08441900500
Hong Kong RGCHKU7147/07E
Electron Microscopy Unit of the University of Hong Kong
Funding Information:

This work was funded by Shanghai Committee of Science and Technology (grant no. 08441900500) and Hong Kong RGC HKU7147/07E. The authors are grateful for all the technical support and guidance from the Electron Microscopy Unit of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorPan, HBen_HK
dc.contributor.authorZhao, XLen_HK
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorZhang, KBen_HK
dc.contributor.authorLi, LCen_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorLam, WMen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorWang, DPen_HK
dc.contributor.authorHuang, WHen_HK
dc.contributor.authorLin, KLen_HK
dc.contributor.authorChang, Jen_HK
dc.date.accessioned2010-10-31T11:16:04Z-
dc.date.available2010-10-31T11:16:04Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of The Royal Society Interface, 2010, v. 7 n. 48, p. 1025-1031en_HK
dc.identifier.issn1742-5689en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125181-
dc.description.abstractBoron plays important roles in many life processes including embryogenesis, bone growth and maintenance, immune function and psychomotor skills. Thus, the delivery of boron by the degradation of borate glass is of special interest in biomedical applications. However, the cytotoxicity of borate glass which arises with the rapid release of boron has to be carefully considered. In this study, it was found that the incorporation of strontium into borate glass can not only moderate the rapid release of boron, but also induce the adhesion of osteoblast-like cells, SaOS-2, thus significantly increasing the cyto-compatibility of borate glass. The formation of multilayers of apatite with porous structure indicates that complete degradation is optimistic, and the spread of SaOS-2 covered by apatite to form a sandwich structure may induce bone-like tissue formation at earlier stages. Therefore, such novel strontium-incorporated borosilicate may act as a new generation of biomaterial for bone regeneration, which not only renders boron as a nutritious element for bone health, but also delivers strontium to stimulate formation of new bones. © 2009 The Royal Society.en_HK
dc.languageengen_HK
dc.publisherThe Royal Society. The Journal's web site is located at http://publishing.royalsociety.org/index.cfm?page=1572en_HK
dc.relation.ispartofJournal of the Royal Society Interfaceen_HK
dc.subjectBone regenerationen_HK
dc.subjectBorate glassen_HK
dc.subjectCytotoxicityen_HK
dc.subjectStrontiumen_HK
dc.titleStrontium borate glass: Potential biomaterial for bone regenerationen_HK
dc.typeArticleen_HK
dc.identifier.emailPan, HB:haobo@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityPan, HB=rp01564en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1098/rsif.2009.0504en_HK
dc.identifier.pmid20031984-
dc.identifier.pmcidPMC2880081-
dc.identifier.scopuseid_2-s2.0-77953083140en_HK
dc.identifier.hkuros180232en_HK
dc.identifier.hkuros176716-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953083140&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue48en_HK
dc.identifier.spage1025en_HK
dc.identifier.epage1031en_HK
dc.identifier.isiWOS:000277991600002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPan, HB=7403295092en_HK
dc.identifier.scopusauthoridZhao, XL=36500583900en_HK
dc.identifier.scopusauthoridZhang, X=7410270971en_HK
dc.identifier.scopusauthoridZhang, KB=16418154300en_HK
dc.identifier.scopusauthoridLi, LC=36499660900en_HK
dc.identifier.scopusauthoridLi, ZY=35784563200en_HK
dc.identifier.scopusauthoridLam, WM=13403256300en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridWang, DP=7407069947en_HK
dc.identifier.scopusauthoridHuang, WH=7407905904en_HK
dc.identifier.scopusauthoridLin, KL=8893315700en_HK
dc.identifier.scopusauthoridChang, J=7601548164en_HK
dc.identifier.citeulike7289688-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats