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Article: Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing

TitleSilver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing
Authors
KeywordsFibroblasts
Keratinocytes
Nanoparticles
Silver
Wound healing
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
Citation
Chemmedchem, 2010, v. 5 n. 3, p. 468-475 How to Cite?
AbstractWith advances in nanotechnology, pure silver has been recently engineered into nanometer-sized particles (diameter < 100 nm) for use in the treatment of wounds. In conjunction with other studies, we previously demonstrated that the topical application of silver nanoparticles (AgNPs) can promote wound healing through the modulation of cytokines. Nonetheless, the question as to whether AgNPs can affect various skin cell types - keratinocytes and fibroblasts - during the wound-healing process still remains. Therefore, the aim of this study was to focus on the cellular response and events of dermal contraction and epidermal re-epithelialization during wound healing under the influence of AgNPs; for this we used a full-thickness excisional wound model in mice. The wounds were treated with either AgNPs or control with silver sulfadiazine, and the proliferation and biological events of keratinocytes and fibroblasts during healing were studied. Our results confirm that AgNPs can increase the rate of wound closure. On one hand, this was achieved through the promotion of proliferation and migration of keratinocytes. On the other hand, AgNPs can drive the differentiation of fibroblasts into myofibroblasts, thereby promoting wound contraction. These findings further extend our current knowledge of AgNPs in biological and cellular events and also have significant implications for the treatment of wounds in the clinical setting. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/124085
ISSN
2015 Impact Factor: 2.98
2015 SCImago Journal Rankings: 1.183
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorLee, PYen_HK
dc.contributor.authorHo, CMen_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorWong, KKYen_HK
dc.date.accessioned2010-10-22T08:10:29Z-
dc.date.available2010-10-22T08:10:29Z-
dc.date.issued2010en_HK
dc.identifier.citationChemmedchem, 2010, v. 5 n. 3, p. 468-475en_HK
dc.identifier.issn1860-7179en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124085-
dc.description.abstractWith advances in nanotechnology, pure silver has been recently engineered into nanometer-sized particles (diameter < 100 nm) for use in the treatment of wounds. In conjunction with other studies, we previously demonstrated that the topical application of silver nanoparticles (AgNPs) can promote wound healing through the modulation of cytokines. Nonetheless, the question as to whether AgNPs can affect various skin cell types - keratinocytes and fibroblasts - during the wound-healing process still remains. Therefore, the aim of this study was to focus on the cellular response and events of dermal contraction and epidermal re-epithelialization during wound healing under the influence of AgNPs; for this we used a full-thickness excisional wound model in mice. The wounds were treated with either AgNPs or control with silver sulfadiazine, and the proliferation and biological events of keratinocytes and fibroblasts during healing were studied. Our results confirm that AgNPs can increase the rate of wound closure. On one hand, this was achieved through the promotion of proliferation and migration of keratinocytes. On the other hand, AgNPs can drive the differentiation of fibroblasts into myofibroblasts, thereby promoting wound contraction. These findings further extend our current knowledge of AgNPs in biological and cellular events and also have significant implications for the treatment of wounds in the clinical setting. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305en_HK
dc.relation.ispartofChemMedChemen_HK
dc.rightsPublished in ChemMedChem: chemistry enabling drug discovery, 2010, v. 5 n. 3, p. 468-475-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFibroblastsen_HK
dc.subjectKeratinocytesen_HK
dc.subjectNanoparticlesen_HK
dc.subjectSilveren_HK
dc.subjectWound healingen_HK
dc.subject.meshFibroblasts - cytology - drug effects-
dc.subject.meshKeratinocytes - cytology - drug effects-
dc.subject.meshNanoparticles - therapeutic use-
dc.subject.meshSilver - therapeutic use-
dc.subject.meshWound Healing - drug effects-
dc.titleSilver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1860-7179&volume=5&issue=3&spage=468&epage=475&date=2010&atitle=Silver+nanoparticles+mediate+differential+responses+in+keratinocytes+and+fibroblasts+during+skin+wound+healing-
dc.identifier.emailHo, CM: rickyho@hkucc.hku.hken_HK
dc.identifier.emailLui, VCH: vchlui@hku.hken_HK
dc.identifier.emailChen, Y: ychenc@hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.emailWong, KKY: kkywong@hku.hken_HK
dc.identifier.authorityHo, CM=rp00705en_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityChen, Y=rp01318en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authorityWong, KKY=rp01392en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1002/cmdc.200900502en_HK
dc.identifier.pmid20112331-
dc.identifier.scopuseid_2-s2.0-77249164618en_HK
dc.identifier.hkuros169104-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77249164618&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue3en_HK
dc.identifier.spage468en_HK
dc.identifier.epage475en_HK
dc.identifier.isiWOS:000275521200016-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLiu, X=36106291400en_HK
dc.identifier.scopusauthoridLee, PY=8212119000en_HK
dc.identifier.scopusauthoridHo, CM=12807243800en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridChen, Y=36463185300en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridWong, KKY=24438686400en_HK

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