Dr Tse, Gary 謝家偉
|University of Cambridge|
|2012||University of Cambridge||MA|
|2015||University of Cambridge||PhD|
|2014||Imperial College London||MBBS|
|2008||University of Cambridge||BA (Hons.)|
|2009||Cambridge Philosophical Society||FCPS|
|2016||Institute of Biomedical Sciences||FIBMS|
|2016||Royal Society of Public Health||FRSPH|
BA Hons MA PhD (Cantab) MBBS AICSM (Imperial) CSci FIBMS FRSPH (UK)
Gary is a newly qualified junior clinician-scientist who took up the Claringbold Medicine Scholarship to start medical training at the University of Cambridge in 2005. As a second-year undergraduate in 2007, he was awarded the Gregon and Benn Award (Trinity Hall, University of Cambridge) for research exchange to Yale University's Department of Biomedical Engineering. In 2008, Gary was selected for the Frankl Award (Trinity Hall, University of Cambridge), The Wellcome Trust and The Physiological Society Vacation Scholarships for cardiovascular research at Cambridge, and a Master's scholarship for MPhil study in Computational Biology at the Cambridge-MIT Institute, which he declined to take up a BBSRC CASE Collaborative Doctoral Training Award, as 1 of the 3 recipents across three Departments selected from an open recruitment exercise. He conducted research in cardiovascular MRI at the Royal Brompton Hospital as a clinical student of Imperial College London. He started a Master of Public Health (MPH) degree in 2014 (2016 completion date).
Gary received his PhD from Cambridge in July 2015, joining HKU's LKS Faculty of Medicine in its School of Biomedical Sciences (formerly the Department of Biochemistry) as Assistant Professor one month later. To date, he is the first professoriate staff member in the Faculty to have submitted > 30 first author publications within a 12-month period whilst having the highest teaching commitments (> 185 hours). In 2016, he was awarded the Croucher Foundation Clinical Assistant Professorship at The Faculty of Medicine, The Chinese University of Hong Kong.
Gary has been elected a Fellow of the Cambridge Philosophical Society (2009), Linnean Society of London (2014), Royal Society of Public Health (2016) and Institute of Biomedical Sciences (2016) and is a Chartered Scientist of the United Kingdom (2016).
With a track record of > 30 publications, > 300 citations and an h-index of 11, Gary's work (impact factor in brackets) has been published in journals such as Heart (5.6), Acta Physiologica (Oxford) (4.1), Frontiers in Physiology (4.0), PLoS ONE (3.1), the official journals of the European Heart Rhythm Association, Europace (4.0), and of the Japanese Heart Rhythm Society and the Asia Pacific Heart Rhythm Society, Journal of Arrhythmia.
Publications: 32, Citations: > 300, H-index: 11
Three research themes: pre-clinical cardiac electrophysiology, clinical cardiac electrophysiology, endothelial dysfunction in cardio-metabolic disorders
Collaborations with colleagues in China (Hong Kong and the Mainland) and abroad:
- HKU (School of Biomedical Sciences)
- HKU (Gerontology Research Laboratory)
- HKU (Stem Cell and Regenerative Medicine Consortium)
- CUHK (School of Biomedical Sciences)
- CUHK (Division of Cardiology, Department of Medicine and Therapeutics)
- CUHK (Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics)
- Tongji Medical School (Department of Cardiology)
- Imperial College London (Faculty of Medicine)
i) Pre-clinical cardiac electrophysiology
To elucidate the molecular mechanisms underlying atrial and ventricular tachycardia using an ex vivo mouse model in Langendorff perfusion mode by monophasic action potential and bipolar electrogram methods during electrical pacing. Our work is largely performed at the systems level, attempting to explain arrhythmogenesis by abnormalities in conduction (e.g. reduced conduction velocity, CV; increased CV dispersion) and repolarization (e.g. prolonged or shortened action potential duration, APD; increased transmural dispersion of repolarization, TDR; reduced refractory period, RP), as well as dynamic substrates of abnormal CV and APD restitution.
For an introduction to cardiac electrophysiology, the reader is directed to the following papers:
1. Tse, G.*, Yeo, J.M. (2015) Conduction abnormalities and ventricular arrhythmogenesis: the roles of sodium channels and gap junctions. International Journal of Cardiology Heart & Vasculature 9:75-82. PMID: 26839915. DOI: 10.1016/j.ijcha.2015.10.003
2. Tse, G.* (2015) Mechanisms of cardiac arrhythmias. Journal of Arrhythmia DOI: 10.1016/j.joa.2015.11.003
3. Tse, G.*, Wong, S.T., Tse, V., Lee, Y.T., Lin, H.Y., Yeo, J.M. (2016) Cardiac dynamics: alternans and arrhythmogenesis. Journal of Arrhythmia.
4. Tse, G.*, Wong, S.T., Tse, V., Yeo, J.M. (2016) Depolarization vs. repolarization: what is the mechanism of ventricular arrhythmogenesis underlying sodium channel haploinsufficiency in mouse hearts? Acta Physiologica (Oxford). PMID: 27084434. DOI: 10.1111/apha.12694. IF 4.4
5. Tse, G.*, Wong, S.T., Tse, V., Yeo, J.M. (2016) Monophasic action potential recordings: which is the recording electrode? Journal of Basic and Clinical Physiology and Pharmacology.
6. Tse, G.*, Lai, E.T., Yeo, J.M., Tse, V., Wong, S.H. (2016) Mechanisms of electrical activation and conduction in the gastrointestinal system: lessons from cardiac electrophysiology. Frontiers in Physiology. DOI: 10.3389/fphys.2016.00182. IF 4.0
7. Tse, G.*, Lai, E.T., Yeo, J.M., Yan, B.P. (2016) Electrophysiological mechanisms of Bayés syndrome: insights from clinical and mouse studies. Frontiers Physiology. DOI: 10.3389/fphys.2016.00188. IF 4.0
8. Choy, L., Yeo, J.M., Tse, V., Chan, S.P., Tse, G.* (2016) Cardiac disease and arrhythmogenesis: mechanistic insights from mouse studies. International Journal of Cardiology Heart & Vasculature. 12:1-10. DOI: 10.1016/j.ijcha.2016.05.005.
9. Tse, G.*, Lai, E.T., Lee, A.P., Yan, B.P., Wong, S.H. (2016) Electrophysiological mechanisms of gastrointestinal arrhythmogenesis: lessons from the heart. Frontiers in Physiology. IF 4.0
10. Tse, G.*, Yeo, J.M., Chan, Y.W., Lai, E.T., Yan, B.P. (2016) What is the arrhythmic substrate in viral myocarditis? Insights from clinical and animal studies. Frontiers in Physiology. DOI: 10.3389/fphys.2016.00308. IF 4.0
His latest work aims to understand the pathogenesis of tachycardia-bradycardia syndrome, an under-investigated clinical entity thought to be a variant of sick sinus syndrome, by examining mRNA expression of key ion channel genes responsible for pacemaker activity in excised sinoatrial nodal tissue using RT-PCR, and correlating these with electrophysiological parameters such as sinus node recovery time, intrinsic and resting heart rates measured in vivo:
11. Chen, Z., Sun, B., Tse, G., Jiang, J., Xu, W. (2016) Reversibility of both sinus node dysfunction and reduced HCN4 mRNA expression level in an atrial tachycardia pacing model of tachycardia-bradycardia syndrome in rabbit hearts. International Journal of Clinical and Experimental Pathology (accepted). IF 1.6
ii) Clincial cardiac electrophysiology
Stratification and prediction of arrhythmic risk and sudden death in human populations
12. Tse, G.*, Yan, B.P. (2016) Novel arrhythmic risk markers incorporating QRS dispersion: QRSd x (Tpeak-Tend) / QRS and QRSd x (Tpeak-Tend) / (QT x QRS). Annals of Noninvasive Electrocardiology. IF 1.6
13. Tse, G.* (2016) (Tpeak-Tend)/QRS and (Tpeak-Tend)/(QT x QRS): novel markers for predicting arrhythmic risk in Brugada syndrome. Europace. IF 3.0
iii) Inflammation and endothelial dysfunction in cardio-metabolic disorders
14. Tse, G.*, Yan, B.P., Chan, Y.W., Tian, XY., Huang, Y. (2016) Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis. Frontiers in Physiology. DOI: 10.3389/fphys.2016.00313. IF 4.0
To explore possible reversal of endothelial dysfunction in cardio-metabolic disorders by pharmacological methods, using molecular techniques such as RT-PCR, scanning electron microscopy, histology, immunohistochemistry and western blotting accompanied by ultrasound assessment of vessel structural and flow characteristics in vivo.
15. Hu, Z., Chen Z., Wang, Y., Jiang, J., Tse, G., Xu, W., Ge, J., Sun, B. (2016) Effects of granulocyte colony-stimulating factor on rabbit carotid and swine heart models of chronic obliterative arterial disease. Molecular Medicine Reports (accepted). IF 1.6
To determine the role of tight and gap junction proteins in the pathogenesis of atherosclerosis:
16. Sun, B., Chen, Z., Gu, J, Tse, G., Jiang, J., Huang, F., Zhao, C. (2016) The roles of tight and gap junctions in the pathogenesis of high fat diet-induced atherosclerosis. International Journal of Clinical and Experimental Pathology. IF 1.6
MBBS I: Introduction to the Art and Science of Medicine (3 lectures)
MBBS II: Respiratory System Block (1 lecture), Cardiovascular System Block (3 lectures), Gastroenterology System Block (3 lectures)
MBBS III: Haematology System Block (3 lectures)
BSc Science: Cardiac Electrophysiology (5 lectures)
Tutor for MBBS I, II and III
1. Interview Panel Member, MBBS Admissions, Li Ka Shing Faculty of Medicine, University of Hong Kong (2015-2016)
2. Internal Examiner, Li Ka Shing Faculty of Medicine, University of Hong Kong (2015-2016)
3. Member, MBBS I Planning Group, Li Ka Shing Faculty of Medicine, University of Hong Kong (2016)
4. Member, Education Committee, Division of Biochemistry, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong (2015-2016)
5. Member, Board of the Faculty of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong (2015-2016)
Academic and Professional Activities
1. Honorary Lecturer, Accident & Emergency Training Centre, Hospital Authority (2016)
2. Invited Reviewer, Academic Journals (e.g. Naunyn-Schmiedeberg’s Archives of Pharmacology, PLoS ONE)
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2016-06-01||Croucher Foundation Clinical Assistant Professorship: The Croucher Foundation, Hong Kong||Research Achievement|
|Term Period||Position||Professional Societies|
|07/2016-present||Member||Institute of Cardiovascular Science and Medicine|
|Spoken Language(s) (EN)||Spoken Language(s) (ZH)|
|Written Language(s) (EN)||Written Language(s) (ZH)|
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