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Professor Sun, Hongzhe 孫紅哲

Title:
Professor, Chair of Chemistry
Professor
Norman and Cecilia Yip Professor in Bioinorganic Chemistry
Associate Vice-President

Department:
President's Office
Department of Chemistry

Faculty:
Faculty of Science

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
 
ITS/124/17Discovery and Preclinical Evaluation of Bismuth(III) Complexes with Porphyrins and Thiolates as New Antagonists Against Side-effect of Cisplatin13997242017
 
R7070-18Combination approach to combat metallo-β-lactamase positive superbugs136860872018
 
17305415Antimicrobial activities of bismuth complexes beyond H. pylori10583622015
 
InP/100/18Discovery and Preclinical Evaluation of Bismuth(III) Complexes with Porphyrins and Thiolates as New Antagonists Against Side-effect of Cisplatin2436002017
 
HKU 704909PNickel (Ni2+) Trafficking between Metallochaperone Proteins6200002009
 
HKU 705310PStructure-based study of metallodrug binding to transferrin10950002010
 
HKUST 3/04CBioactive substances from marine microbes2250002004
 
HKU 704612PLighting up metalloproteins: from nickel-binding to cellular functions11500002012
 
HKU 7110/02PRecognition of antimonials by lactoferrin and trypanothione: implications for uptake, activation and targeting3800002002
 
HKU 704207PChemical and Biochemical Characterization of the Histidine- and Glutamine-rich Protein, Hpn-like: Implications for the Role of Histidine-rich Proteins in Microorganisms5575002007
 
HKU 7039/04PCharacterization of a nickel-storage protein Hpn: its relation with bismuth antiulcer drugs2830002004
 
HKU 7040/05PMetal-based Drug Design: Bismuth Complex as an Antiviral Agent3210002005
 
HKU 703808PThe Putative N-terminal Metal-binding Domain of Copper Transporter (hCtr1) and its Role in Copper(I) and Platinum Anticancer Drug Transport3437002008
 
C7034-20EMass cytometry, a multiplexed single-cell technology for chemical biology and precision medicine120000002020
 
HKU 7512/05MFunctional and structural characterization of lipoprotein MtsA in MtsABC responsible for transport of iron and other metal ions in <I>Streptococcus pyogenes</I>14609572005
 
17306323Integrative metallomic approach for deciphering the role of metals in COVID-19 immunity and discovering new biomarkers8770792023
 
N_HKU 720/02The molecular basis of biological functions of the neuronal growth inhibitory factor (metallothionein-3)7730002002
 
N/ABioactive substances from marine bacteria1000002003
 
HKU 7043/06PBiocoordination chemistry of bismuth and antimony: a metalloproteomic study5384602006
 
HKU 1/07CStructure-function of metal-binding proteins in Helicobacter pylori51000002007
 
F-HK27/08TA metallomic approach to analyze bismuth- and nickel-binding proteins in cells306002008
 
N_HKU 752/09Tracking metals in cells by metallomics: insights into the metal-associated pathophysiological processes7440002009
 
N/AStructure-function relationship of metal-binding proteins6490802010
 
HKU 703913PSingle cell-based metallomics for metallodrugs6565212013
 
17304614Integrative approach for matching arsenic to proteins6806822014
 
ITS/085/14Development of Bismuth Compounds as Novel Antagonists against Toxicity of Anticancer Drug Cisplatin13823002014
 
ITS/278/20Development of Novel Inhibitors for Combatting SARS-CoV-2 Infection11954022020
 
PiH/114/21Development of Novel Inhibitors for Combatting SARS-CoV-2 Infection4891602021
 
SRFS2122-7S04Discovering Bismuth and Relevant Metallo-agents for Medicinal Applications: From Molecular Mechanism of Action to Translational Research77983802021
 
F-HKU704/19Discovery of metallo-agents as antimicrobial resistance breakers540002019
 
17333616Biophysical/biochemical and functional validation of putative bismuth targets in Helicobacter pylori to elucidate the molecular mechanism of action of bismuth drugs5408242016
 
17307017Systemic approach for uncovering the roles of metals in biology and medicine: mechanism of actions of antimicrobial bismuth drugs5228982017
 
17308921Mechanistic investigation of antimicrobial activity of bismuth tropolone compounds by (metallo)proteomic approaches6660152021
 
N/AMetals in Biology and Medicine: from Molecular Image to Drug Resistance5930002018
 
17318322Mechanistic insights into anti-SARS-CoV-2 activity of bismuth compounds: nsp10/nsp14 as potential targets 12300002022
Co-Investigator
StatusProject CodeProject TitleAmountFunding Year
 
02040192Determine the functions of the putative metal-binding domain of SARS-CoV helicase8050002004
 
SEG_HKU02High-Performance Tandem Mass Spectrometry Facility for Functional Proteomics and Metabolomics86000002008
 
HKU6/CRF/11GStrategic research of hormones and their receptors in the water homeostatic axis: from molecular mechanisms to anti-hypertensive drug design56250002011
 
T11-709/21-NEcology, molecular virology and pathogenesis of SARSCoV-2: From bedside to bench and back311360002021
 
AR170011Effect of bismuth compound as anti-oxidant for iron overload protection2100002015
 
2207101537Development of non-nucleoside inhibitors of SARS-CoV-2 RdRp-nsp7-nsp8 replication complex5000002022
 
HKUST 1/00CBioactive substances from marine bacteria2250002000
 
HKU 2/06CPeptidomimetics: Design, Synthesis and Biomedical Applications34000002006
 
N_HKU767/22Development of novel anti-coronavirus drugs targeting the multi-domain SARS-CoV-2 NSP3 protein12447502022
 
ITS/243/09Development of Novel Nanopolymers for Cancer Gene Therapy9781052009
 
HKUST 3/04CBioactive substances from marine microbes4350002004
 
HKUST 1/00CBioactive substances from marine bacteria2250002002
 
01030182Helicases as antiviral drug targets8049992003
 
17119819Novel approaches to combating the keystone periodontopathogen Porphyromonas gingivalis in infected host cells via multi-omic integrative analyses11160192019
 
HKU 776108MDevelopment of an Aptamer-Nanoparticle Based Rapid Diagnostic Test for Malaria6599802008
 
ITS/276/00Fouling control biotechnologies using immobilized bacteria and bacterial metabolites14020002000
 
HKU 7227/02MMolecular dynamics of iron transport11803402002
 
20190732Host PFKFB3-dependent glycolytic reprogramming as a broad-spectrum antiviral strategy14759202020
 
HKU 7341/03MApplication of chemical genetic approaches to dissect the molecular basis of virulence and dimorphism in Penicillium marneffei13370002003
 
C7002-23YDevelopment of non-nucleoside inhibitors of SARS-CoV-2 RdRp-nsp7-nsp8 replication complex45601792024