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Professor Sham, Pak Chung 沈伯松

Title:
Chief of Internal Affairs
Chair Professor in Psychiatric Genomics
Scientific Staff of Genome Research Centre
Clinical Chair Professor
Professor: Chair of Psychiatric Genomics

Department:
Department of Psychiatry

Faculty:
Li Ka Shing Faculty of Medicine

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
 
N/AGenetic Variation and Genomic Architecture in Development, Health and Disease5987502017
 
17128515Method and software tool for estimating and dissecting the heritability of complex diseases11672882015
 
HKU 777511MMethod and Software for Personal Risk Profiling of Complex Diseases9450002011
 
HKU 7669/06MOptimal design of genome-wide association studies for multifactorial diseases5325002006
 
HKU 774707MGenome-wide association study of schizophrenia17989902007
 
HKU 774710MPredicting and preventing schizophrenia in the mouse model.12021832010
 
HKU 7579/05MA systematic screen for schizophrenia susceptibility loci in high-LD, gene-rich chromosomal regions implicated by meta-analysis of whole genome linkage scans7012932005
 
HKU 776412MBioinformatics tools for identifying disease loci from exome sequencing data10980002012
 
N/AStatistical Genetics: From Haplotype Maps to Disease Susceptibility Genes5800002004
 
HKU 768610MTo determine the functional variants of candidate genes identified by Genome-wide Association Study of Osteoporosis10000002010
 
HKU 776513MStatistical methods for characterizing the genetic component of polygenic diseases6900892013
 
01121616Mutational spectrum for dilated cardiomyopathy in Hong Kong9172702013
 
N_HKU736/14Schizophrenia-related de novo and compound heterozygous mutations10986182014
 
17121414A novel computational framework to identify transcription factor-DNA interaction for cancer genomics12826842014
 
C7019-16EEstablishment of Third Generation Sequencing Core Facility64445142016
 
17124017Integrating functional annotation and statistical information in novel set-based rare-variants association tests for complex diseases6293652017
Co-Investigator
StatusProject CodeProject TitleAmountFunding Year
 
C7044-19GFunctional and systems analyses of regulatory networks controlling cell fate and lineage development of intervertebral disc cells80984442019
 
17119423Characterizing clinical and functional outcomes of neurological soft-signs in first-episode schizophrenia: A 10-year follow-up study5353682023
 
2211100938PDF/RAP Scheme (47th Round) - New Position02022
 
20212381Risk prediction models of mortality and major complications of Chinese patients with severe mental illness and co-existing diabetes in Hong Kong: a population-based cohort study8401122022
 
HKU 766708MGene Identification for Osteoporosis using a Two Stage Genome-wide Association Strategy in the Chinese Population21621902008
 
02132236Development of multivariate gene-based association analysis approaches for endophenotypes of complex diseases and their application to genetic mapping in a Chinese schizophrenia sample9896402014
 
01121796A transethnic meta-analysis of genome-wide association studies for Hirschsprung disease788002013
 
17605815Attention-deficit/hyperactivity disorder and child maltreatment: A population-based study4466502015
 
HKU 775208MDetecting genes and functional analysis of a novel gene (Cer1) significantly associated with bone mineral density (BMD) in mice.10441862008
 
N_HKU 715/07To identify osteoporosis susceptibility gene(s) at chromosome 2q,5q,7p, and 13q in Chinese7990002007
 
01121516Uncovering the genetic lesions underlying the most severe form of Hirschsprung (HSCR) disease by whole genome sequencing (WGS): a pilot study in 8 family trios10000002013
 
02132216Genetic risks for chronic periodontitis: A genome-wide association study9999802014
 
03142856Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma11966082015
 
HKU 767407MTo identify susceptibility gene(s) at the BMND2 locus on chromosome 1q21-23 for bone mineral density variation in Chinese11186582007
 
17120622The influence of emotion-behaviour decoupling on clinical and functional outcomes in patients with schizophrenia: Evidence from two independent longitudinal cohorts7890552022
 
HKU 777612MStudy on genomic structural variations in Hirschsprung disease10000002012
 
17104314Genetics and genomics of anti-thyroid drug induced agranulocytosis9055582014
 
HKU 765808MLarge scale association studies of osteoporosis in Chinese8389992008
 
17125114Meta-Analysis of three GWAS datasets from Hong Kong, Anhui China and UK followed by replication in independent cohorts in Asia and UK for identification of novel susceptibility genes associated with SLE10980002014
 
HKU 778610MDeep Re-Sequencing of Hirschsprung's Disease Candidate Genes10000002010
 
213217Genomic Medicine for All - State of Art Testing for Hong Kong Children with Genetic Conditions19298802013
 
06172266Exploring the role of microRNA in sight-threatening diabetic retinopathy in Chinese patients with type 2 diabetes14999562018
 
HKU 766112MWhole-exome sequencing to uncover causative genes for perinatal biliary atresia8500002012
 
HKU 778213MUncovering the genetic lesions underlying persistent cloaca by whole genome sequencing8227312013
 
11121721Treatment resistance following the first-episode schizophrenia-spectrum disorder: a retrospective case-control study7999522013
 
02131866The International Hirschprung Disease Consortium: follow-up on whole-exome sequencing data5679202014
 
HKU 775608MGenome-wide association study for the identification of genes underlying anorectal malformations12663372008
 
17108717Does methylphenidate treatment increase seizure risk in children and adolescents with Attention Deficit Hyperactivity Disorder?3600002017
 
18192331Mortality among older persons with schizophrenia in Hong Kong7326242020
 
HKU 770411MIdentification of coding variants associated with early-onset and familial systemic lupus erythematosus through whole exome sequencing and replication6500002011
 
HKU 7524/05MTo discover new genes in chromosome 14q11-32 for the determination of osteoporosis and bone mineral density7189572005
 
PR-HKU-1Molecular diagnosis of rare genetic diseases: whole genome sequencing and transcriptomics of biliary atresia, Hirschsprung disease and congenital pulmonary airway malformations49483802020
 
02132726Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study9101762014
 
17118119Identification of novel susceptibility loci for diabetic retinopathy in Chinese patients with type 2 diabetes: an Asian Screening Array analysis11152282019
 
HKU 762308MGenome-wide association mapping of susceptibility loci for symptomatic epilepsy15702952008
 
T12-705/11Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform337050002011
 
04050252Promoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection8049282005
 
HKU 766913MCongenital dilatation of the bile ducts (CCD): a genetic study14722552013
 
15140862Unveiling the characteristics of emerging Staphylococcus lugdunensis sequence type 3 clone by genomics analysis11276082015
 
17109918The biliary atresia genome: a pilot study to model disease from whole genome sequencing data7614002018
 
01121576Whole exome sequencing to uncover genetics variants underlying Congenital Cystic Adenomatoid Malformations8814252013
 
HKU 784611MMeta-Analysis of two Asian GWAS datasets for identification of novel genetic variants associated with systemic lupus erythematosus6500002011
 
HKU 780210MBiomarkers of Obesity-related Cardiometaolic Risks in Chinese6094452010
 
HKU 7679/06MRole of upregulation of toll-like receptor 7 and functional polymorphisms within the toll-like receptor 7 gene in inducing sustained disease remission in chronic hepatitis B infection7545002006
 
HKU 777212MIdentification of a genetic variant for heart defects (CHD) on chromosome 15 in mice8500002012
 
HKU 7672/06MSNP-based genome-wide screen for susceptibility genes for hypertension: a sibling study15669162006
 
HKU 775907MGenetic dissection of Hirschsprung's disease17818132007
 
08193446Towards establishing a genetic risk profile for Hirschsprung disease: pathway-centric approach to model polygenic risk11489042020
 
HKU 766611MWhole-exome sequencing to identify genes underlying Caudal Regression Syndrome7500002011
 
T12C-714/14-RGenetics and Functional Genomics of Neural Crest Stem Cells and Associated Disease: Hirschsprung Disease480000002014
 
02131706Delineating pathogenic mutations in Epstein-Barr virus genomes of nasopharyngeal carcinoma using next generation sequencing technology9997922014
 
04151966Identification and functional characterization of Hirschsprung disease susceptibility genes on chromosome 213325372016
 
06173556Ligament and tendon repair using Lgr5+ interzone cells as progenitor14913082018
 
17146616Unravelling the genetic puzzle of systemic lupus erythematosus (SLE) through comprehensive analyses of genetic association by functional annotation of genes, variants, and genomic regions10168002016
 
01121496Elucidating the genetic basis for early-age onset nasopharyngeal carcinoma in Hong Kong10000002013
 
T12-704/16-RUnderstanding Cancer Stemness in Liver Cancer – From Regulation to Translational Applications285234002016
 
T12-701/17-RTranslational Studies for Elucidating the Tumor Heterogeneity and Molecular Evolution in Metastatic Gastrointestinal Tract Cancers for Personalized Medicine265170002017
 
C7030-18GExploiting the true joint progenitor cell for articular cartilage repair73705852018
 
HKU 762607MDo biomarkers of inflammation and obesity predict the development of hypertension in Hong Kong Chinese?9000392007
 
HKU 7628/06MStudy of the genetic basis of biliary atresia9225002006
 
HKU 762309MGenotype by risk factor interactions in cognitive decline: The Guangzhou Biobank Cohort Study1976502009
 
200507176044Association and Linkage Studies Between Arterial Stiffness and the Fibrillin-1 Gene793802005
 
HKU 762412MThe Impacts of Yoga and Aerobic Exercise on Neuro-cognitive Function and Brain Structure in Early Psychosis - A Randomized Controlled Clinical Trial12482502012
 
01121436Statistical method to identify risk genes of complex diseases based on functional gene sets and networks, with a genetic data mining application to hepatocellular carcinoma9999902013
 
17107314Causative genes for perinatal biliary atresia: a follow-up of whole-exome sequencing6325692014
 
01121306Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis10000002013
 
13142781The relative roles of dopamine dysregulation and psychosocial stressors in later-onset psychosis9737642015
 
01121726Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese9568002013
 
18192311Identification of risk interaction of hypovitaminosis D genetic and environmental factors among Hong Kong infants and toddlers11525002020
 
T11-707/15-RMolecular Basis for Interspecies Transmission and Pathogenesis of Middle East Respiratory Syndrome Coronavirus356200002015
 
T11-705/14-NViral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis580000002014
 
T12-712/21-RTranslating Disease-Mechanism Discoveries to Improve Treatment of Biliary Atresia, an Intractable Newborn Liver Disease384720002021
 
HKU 7520/05MGene-based and haplotype analysis of the estrogen receptor genes for breast cancer susceptibility7189572005
 
AoE/M-06/08Centre for Nasopharyngeal Carcinoma Research800000002009
 
03144016Impact of genetic variants identified in genome-wide association studies and their possible interaction with hypertension on the risk of diabetic retinopathy9405042015
 
10111531Mendelian randomization to causally infer the impact of life-long vitamin D deficiency on Cardiovascular disease and death: implications for community-based cardiovascular prevention9990002012
 
T12-708/12-NFunctional Analyses of How Genomic Variation Affects Personal Risk for Degenerative Skeletal Disorders637500002012
 
AR190060Community-based Youth Mental Wellness Hubs1143020002019
 
N/AA Genome-Wide Association Study on the Predisposition to Colorectal Cancer in the Han Chinese Population in Hong Kong27666382007
 
06171636A sensitized genetic screen to identify and functionally characterize genetic modifiers for hirschsprung disease8405102018
 
HKU 765609MIdentification of functional variants in Neuregulin-1 (NRG1), a newly discovered Hirschsprungs disease gene8029952009
 
17620919Long-term impact of child maltreatment: A population-based longitudinal study8098162019
 
200811159079Clinical implications of genetic variants of the newly discovered type 2 diabetes susceptibility genes in Southern Chinese700002008
 
17119021Network structure and cognitive trajectories of schizotypy in an epidemiological youth sample7524682021
 
02131816Identifying the genetic causes underlying prenatally-diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES)9973802014
 
N/AVariance components models for mapping QTLs6360822006
 
HKU 7590/06MAdipocyte fatty acid binding proteins: new mediators of the metabolic syndrome and coronary atherosclerosis17797002006
 
HKU 767307MSplicing variant profiling in relation to Estrogen Receptor gene expression in Chinese breast cancer8826272007
 
HKU 783813MIdentifying susceptibility genes in the human MHC region independently associated with systemic lupus erythematosus (SLE) in Chinese populations8227312013
 
17124715A longitudinal multimodal MRI investigation for clinical and functional outcome prediction in individuals at clinical high-risk for psychosis: a prospective 2-year follow-up study10267122015
 
17113320Modelling disease mechanisms and risks of congenital bile-duct dilatation using whole exome sequencing and SNP array data9962852020
 
HKU 7514/06MSystematic evaluation and screen of the regions previously linked to osteoporosis in Southern Chinese11325002006
 
03040792The functional role of ICAM3 polymorphism in genetic susceptibility to SARS infection7979692005
 
HKU 781709MMapping Susceptibility Genes for Systemic Lupus Erythematosus (SLE) through a Genome-Wide Association Study7557602009
 
HKU 772413MMolecular characterization of gastric microbiome in individuals at different stages of H. pylori associated gastric carcinogenesis cascade6374002013
 
HKU 763012MExome sequencing of mesial temporal lobe epilepsy with hippocampal sclerosis in parent-offspring trios8500002012
 
HKU 790312HGenetic modeling of schizophrenia endophenotypes in a pan-European twin sample7622812012
 
08193216Metabolomics signature for the prediction of diabetic kidney disease in Chinese patients with type 2 diabetes14938202020
 
17113420A novel bioinformatics framework for curating and analyzing structural variations from whole genome sequencing data9065152020
 
ITS/245/09FPNext-Generation High-throughput and Targeted DNA Sequencing Platforms for Systematic Discovery of Novel Diagnostic Markers of Common Disease58569862009
 
AoE/M-04/04Developmental genomics and skeletal research809740002003