Dr Lee, Calvin Kai Fai 李啟輝
Gamete/Embryo-Female Reproductive Tract interaction plays very important role on successful embryo development, implantation and pregnancy outcomes. Various factors produce from the pre-implantation embryo and/or female reproductive tract (oviductal and uterus) may have paracrine or autocrine roles on fertilization, pre-implantation embryo development and attachment process. We are the first identified embryotrophic factor (C3) and other factors from human oviductal epithelial cells that enhance embryo development in vitro. We are currently investigating how these factors enhance embryo development in vitro.
Hormonal stimulation affects endometrial development in IVF patients, as well as implantation and pregnancy rates. Excessive ovarian stimulation advances endometrium development as well as altering gene expression pattern. We are the first compared the endometrial transcriptomes between natural and stimulated cycle of IVF patients and identified dys-regulating of genes in various signaling pathways important for Endometrial Receptivity. One of these is Wnt-signaling pathway. Furthermore, we also found important roles of dicer and miRNAs in regulating embryo development, implantation and invasion process. We are now using in vitro (cell line co-culture) and in vivo (animal) models to dissect the molecular changes during the implantation process.
I got my Ph D in Biochemistry from the Chinese University of Hong Kong and trained as postdoctoral training at Tufts University, Massachusetts, USA. I joint the Department of Obstetrics and Gynaecology at The University of Hong Kong as Research Assistant Professor in 1998. I was promoted to Assistant Professor and Associate Professor in 2001 and 2008, respectively. I am currently the President of the Hong Kong Society for Reproductive Medicine, Honorary Secretary of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, as well as members of various international and local societies. I have published more than 80 original articles in international journals with H index 22 (total citation >1200). I and my research team have obtained many international and local awards including “The Best Poster Award of Society for the Study of Reproduction (SSR) – Southeast Asia Region”.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2008-11-01||Best Oral Presentation Award: Glycodelin-A suppresses human extravillous cytotrophoblast invasion through modulating matrix metalloproteinases activities.: The Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, 30 November 2008, Hong Kong.||Research Achievement|
|2010-06-01||MicroRNA-135a Regulates Early Embryo Development Through Mediating Expression of E3 Ubiquitin Ligase Seven In Absentia Homolog 1 (SIAH1): The 26th Annual Meeting of the European Society of Human Reproduction and Embryology.||Research Achievement|
|2014-05-01||Poster Award (Title of poster presentation: In-vitro study on the effect of ulipristal acetate on human embryo implantation using a trophoblastic spheroid and endometrial cell co-culture model): 13th Congress of the European Society of Contraception and Reproductive Health||Research Achievement|
|2002-12-01||Outstanding presentation award: The 7th Research Postgraduate Symposium, The University of Hong Kong, Dec 7, Hong Kong.||Research Achievement|
|2010-05-01||Excellent Poster Presentation: MicroRNA-34c is important for the first cell division in mouse embryos: First SKLAB Symposia on Frontiers in Preimplantation Biology 8-12 May 2010, Beijing||Research Achievement|
|2007-11-01||Best poster presentation award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances preimplantation embryo development by suppressing reactiveoxygen species (ROS) production.: The Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, 11 November 2007, Hong Kong.||Research Achievement|
|2010-01-01||Best Abstract Award: MicroRNA let-7 is important in embryo implantation: Annual Scientific Meeting of the Hong Kong Society for Reproductive Medicine 21 January 2010||Research Achievement|
|2010-06-01||Basic Science Award: MicroRNA-135a regulates early embryo development through mediating expression of E3 Ubiquitin Ligase Seven In Absentia Homolog 1 (SIAH1): 26th Annual Meeting of European Society for Reproduction and Embryology, 27-30 June 2010, Rome||Research Achievement|
|2012-11-01||The estrogen-regulated Let-7a plays a pivotal role during blastocyst activation via its effect on Vav3: Best Oral Presentation award - The 7th Huaxia conference||Research Achievement|
|2008-11-01||Best Poster Award: Cumulus glycodelin stimulates human spermatozoa-zona binding mediated by the elevation of intracellular calcium concentration: The Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, 30 November 2008, Hong Kong.||Research Achievement|
|2011-08-01||HKU Strategic Research Areas & Themes “Reproduction and Development” Best Research Output Award 2011 (2nd Prize): Glycosylation failure extends to glycoproteins in gestational diabetes: Evidence from reduced alpha 2-6 sialylation and impaired immunomodulatory activities of pregnancy-related glycodelin-A. Diabetes. 2011;60(3):909-17.: HKU Strategic Research Areas & Themes “Reproduction and Development”||Research Achievement|
|2012-05-01||Excellent Poster Presentation: Involvement of microRNA Lethal-7a in the Regulation of Embryo Implantation in Mice: 2nd SKLRB Symposia on “Frontiers in Reproductive Biology||Research Achievement|
|2011-05-01||Best Poster Award - Ovarian stimulation modulates steroid receptors expression and spheroids attachment in peri-implantation endometria: studies on natural and stimulated cycles: Pacific Rim Society for Fertility and Sterility||Research Achievement|
|2013-07-01||Concomitant Regulatory Effect of Lin28 and Dicer on MicroRNA Let-7a Expression Alters the State of the Blastocysts During Embryo Implantation: Regional Best Abstract Award (Southeast Asia) - Society for the Study of Reproduction, USA||Research Achievement|
|Term Period||Position||Professional Societies|
|01/2000 - Present||Member||The Society of the Study of Reproduction, USA|
|01/2004 - 12/2008||Member||Hong Kong Society of Mass Spectrometry|
|01/2004 - Present||Member||The Hong Kong Society of Endocrinology, metabolism and reproduction, HK|
|11/2006 - Present||Council Member||The Hong Kong Society of Endocrinology, metabolism and reproduction, HK|
|01/2000 - 12/2006||Member||The Hong Kong Society of Reproductive Medicine, HK|
|01/2007 - 12/2012||Hon Secretary||The Hong Kong Society of Reproductive Medicine, HK|
|05/1994 - Present||Member||American Association on the Advanced of Science (AAAS) member, USA|
|01/2013 - 12/2014||Hon Secretary||The Hong Kong Society of Endocrinology, metabolism and reproduction|
|01/2013 - 12/2014||President||The Hong Kong Society of Reproductive Medicine|
|05/2015 - 04/2017||Grant Review Board Member||Health and Medical Researcg Fund|
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