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Our research focuses on the investigation of molecular basis of human cancer progression, aim to improve treatment strategies and ultimately patient survival. As a first step, we have deciphered liver cancer genomics and published the first paper on the human liver cancer genome-wide expression profiles, and employed the expression profiles in defining the clonality of multiple nodular liver cancer. Based on the differential expression pattern, continuation research included identification of potential therapeutic target, the novel growth factor granulin-epithelin precursor (GEP), and consolidated its role on liver cancer growth, invasion, chemoresistance, cancer stem cell properties and antibody targeted therapy.