HKU ResearcherPage: Peiris, Joseph Sriyal Malik

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Professor Peiris, Joseph Sriyal Malik
裴偉士
  • Tam Wah-Ching Professorship in Medical Science; and Professor: Chair of Virology
  • Scientific Director of HKU Pasteur Research Centre
  • Tam Wah-Ching Professor in Medical Science
Co-Investigator
Project Code Amount Title Funding Year
1 11100862 612372 Vitamin D and risk of influenza in children and adults in Hong Kong 2011/2012
2 11100882 999700 The epidemiology of influenza in households of school-age children 2011/2012
3 11100892 702376 Estimating the epidemic curve of influenza among healthy adults in Hong Kong during 2010-2011 Phase 1: Pandemic influenza A/H1N1 2011/2012
4 HKU 777407M 740731 Immune defense of human gammadelta-T cells against Influenza a viruses 2007/2008
5 10091272 994837 Influenza-like illness and viral aetiology in Hong Kong children 2010/2011
6 HKU 7430/03M 803000 A role for apoptogenic gene PKR in regulating TNF and cytokine expression in Avian influenza H5N1 infections 2003/2004
7 03040772 794584 The role of dentritic cells in SARS coronavirus infection 2005/2006
8 HKU 783810M 591600 Role of influenza hemagglutinin glycoprotein in activation of dendritic cells and induction of effective immune response through C-type lectin receptors 2010/2011
9 HKU 7334/01M 1004000 Molecular evolution studies on H5N1/97 and related avian influenza viruses 2001/2002
10 CHP-CE-03 6628154 Effectiveness of vaccinating children in reducing influenza among household contacts - a community based, randomized controlled trial 2008/2009
11 09080532 333880 Effect modifications of lifestyle factors on risk of mortality associated with influenza in an elderly cohort 2009/2010
12 HKU 763707M 670717 A comparison study of humoral and cellular immune responses in very young infants after intradermal versus intramuscular injection of influenza vaccine 2007/2008
13 08070762 799584 Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo 2008/2009
14 HKU 7396/03M 624000 A population based study of hospitalization disease burden for respiratory viral infections in children 2003/2004
15 PHE-21 1542500 A longitudinal community study of influenza virus infections in Hong Kong 2009/2010
16 AF/90/97 4945000 Oral DNA vaccines 1997/1998
17 PHE-2 528738 The attack rate, transmission dynamics and viral evolution in a cohort of Hong Kong families during an epidemic of novel influenza virus (H1N1) 2009/2010
18 10091062 995836 Role of retinoic acid inducible gene-1, toll-like receptor-3 and -8 in cytokine induction by influenza A H5N1 and pandemic H1N1 viruses in primary human cells 2010/2011
19 04050252 804928 Promoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection 2005/2006
20 PHE-20 1399032 A detailed longitudinal study of infection attack rates among healthy adults in Hong Kong during the epidemic of the human swine influenza A/H1N1 virus in 2009 2009/2010
21 02040202 805000 Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections 2004/2005
22 HKU 7225/02M 1747000 Genetic determinants of influenza virus for inter-species transmission: studies using a reverse genetic approach 2002/2003
23 03040792 797969 The functional role of ICAM3 polymorphism in genetic susceptibility to SARS infection 2005/2006
24 HKU 7305/02M 876000 Mechanism of HIV suppression of cytokine expression: Tat and PKR interactions 2002/2003
25 HKU 7013/99M 568700 The impact of fluconazole exposure on the differential expression of phenotypic and genotypic attributes of oral Candida isolates in HIV infection 1999/2000
26 10090142 819448 The role of balanced hemagglutinin-neuraminidase activity on the genesis of transmissible NA inhibitor-resistant variants in seasonal and novel pandemic influenza A H1N1 viruses 2009/2010
27 07060482 789648 Humanized mouse as a model to study the antiviral activity of human gammadelta-T cells against human and avian influenza A viruses in vivo 2007/2008
28 04050132 158028 Occult respiratory viral infections in coronial autopsies - a pilot project 2005/2006
29 HKU 776810M 1200000 A longitudinal community study of influenza virus infections in Hong Kong 2010/2011
30 04050212 799656 Estimation of the effect of influenza on cardiorespiratory and all causes mortality in tropical and sub-tropical climates - a comparative study between Hong Kong, Singapore and Guangzhou for influence of seasonality and meteorological conditions 2005/2006
31 08070632 551400 Viral shedding, natural clinical history and transmissibility of influenza 2007/2008
32 08070562 795660 Epidemiological implications of viral evolution from one generation of human influenza infection to the next 2008/2009
33 10090272 925260 A longitudinal study of infection attack rates among hospital outpatients in Hong Kong during the epidemic of the human swine influenza A/H1N1 virus in 2009 by tracking temporal changes in age-specific seroprevalence rates 2009/2010
34 HKU 7532/05M 1105914 Immune response of cord blood macrophages and dendritic cells to the 1997 and 2004 strains of avian influenza viruses 2005/2006
35 11100582 398440 Estimation of excess mortality and hospitalization associated with pandemic influenza 2009 2011/2012
36 03040302 735294 Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS 2005/2006
37 HKU 7553/03M 500000 Rapid accurate diagnostic assay for the SARS coronavirus 2003/2004
38 10091132 936436 The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract 2010/2011
39 HKU 761009M 700000 Influenza A (H5N1) virus infection in human primary type I and type II alveolar epithelial cells: Cell tropism, inflammatory responses and apoptosis 2009/2010
40 HKU 7543/03M 450000 Rapid molecular diagnosis of SARS coronavirus 2003/2004
41 HKU 765811M 850000 Efficacy of face masks to prevent influenza virus transmission: an experimental study 2011/2012
42 06060552 799378 Replication and pathogenesis of avian influenza A (H5N1) viruses in polarized human bronchial and alveolar epithelium 2006/2007
43 03040872 249564 Sialic acid and receptor expression in normal respiratory tract, H5N1 influenza and non-avian influenza cases 2004/2005
44 HKU 773507M 667673 Tissue tropism and cytokine production within the upper and lower respiratory tract of humans following influenza virus infection 2007/2008
45 11100562 994616 A Randomised Controlled Trial of Traditional Chinese Medicine (Yu Ping Feng San) for influenza prophylaxis in elderly residential care homes in Hong Kong 2011/2012
46 03040712 800648 Primary human lung epithelial cells as an in-vitro model to study the pathogenesis of SARS coronavirus infection 2005/2006
47 06060562 743648 Role of cyclooxygenase-2 (COX-2) influenza A (subtype H5N1) viral pathogenesis and the potential use of its inhibitors for the therapy of H5N1 disease 2006/2007
48 HKU 7356/03M 1112000 Roles of segment-specific vRNA sequences of influenza A virus in viral replication, transcription and gene expression 2003/2004
49 01030391 596985 Seroepidemiological prevalence survey of SARS-associated coronavirus antibody in children residing in Amoy Garden compared to a control group in southern district 2003/2004
50 2536654 A controlled trial of masks and hand hygiene for reducing influenza transmission 2006/2007
51 11101002 875948 Neutrophil mediated host-responses during influenza A virus infection, an in vitro study 2011/2012
Principal Investigator
Project Code Amount Title Funding Year
1 HKU 773707M 1397226 Effector roles of cytokine cascades in the pathogenesis of human H5N1 disease 2007/2008
2 HKU 479/96M 761000 Human herpesvirus 6 and 7 infections in bone marrow transplant recipients: differentiation of active infection from chronic persistence and correlation with disease 1996/1997
3 3523360 Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) 2000/2001
4 4519674 Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) 2001/2002
5 JRS00/05 72706 Virus-macrophage interactions: a basis for immunopathology of H5N1 influenza 1999/2000
6 HKU 7620/06M 1054500 Role of toll-like receptors and retinoic acid-inducible gene 1 in the induction of cytokines in SARS-coronavirus infected human primary macrophages 2006/2007
7 HKU 7459/03M 1715400 Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? 2003/2004
8 HKU 7092/99M 935000 Interactions between avian influenza A H5N1 virus and macrophages: a basis for immuno-pathology 1999/2000
9 04050492 800096 Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens 2005/2006
10 HKU 7542/03M 1012000 Genetic variation of the SARS coronavirus: molecular epidemiology and antigenic variation 2003/2004
11 01030172 824164 The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis and viral virulence 2003/2004
12 1361060 Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) 1999/2000
13 HKU 7335/02M 876000 The application of DNA arrays to characterise the avian influenza gene pool in southern China 2002/2003
14 HKU 7286/01M 1582000 Human herpesvirus 6 (HHV-6) and HHV-7 infections: reactivation, latency and viral interactions 2001/2002
15 HKU 1/05C 4600000 Pathogenesis, cell signaling and virus evolution of avian influenza A (H5N1) 2005/2006
16 03040722 729236 The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection 2004/2005
17 HKU 7314/97M 589680 Public health hazards associated with verocytotoxin-producing Escherichia coli 1997/1998
18 HKU 776110M 606982 The role of Toll-like receptor 10 (TLR10) as an innate immune sensor for respiratory viral infections 2010/2011
19 156000 Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand) 2007/2008
20 AoE/M-12/06 76000000 Control of Pandemic and Inter-pandemic Influenza 2007/2008
21 309383 Virology and pathogenesis of avian influenza and SARS 2005/2006
22 7720751 The Zoonotic potential of influenze viruses in Southeastern China 2001/2002
23 3154358 The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo 2006/2007

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