HKU ResearcherPage: Chung, Sookja Kim

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Professor Chung, Sookja Kim
金淑子
  • Professor
Co-Investigator
Project Code Amount Title Funding Year
1 HKU 7645/06M 843500 Hypoxia inducible factor 1α as a mediator of obesity-induced chronic inflammation, aberrant production of adipokines, and insulin resistance 2006/2007
2 HKU 763411M 750000 The role of astrocytic ET-1 in neuropathic pain: A study using astrocytic specific ET-1 over-expressing mice (GET-1) 2011/2012
3 HKU 2/02C 3000000 Understanding gene function and molecular bases of disease using transgenic and gene targeting technology 2002/2003
4 HKU 410/94M 623000 The production of a transgenic mouse model of autoimmune thyroiditis and the study of induction of tolerance to an organ specific autoantigen in transgenic mice expressing thyroid peroxidase in the thymus 1994/1995
5 HKU 2/01C 5000000 Genomic approaches to uncover functionally relevant signalling pathways in craniofacial development 2001/2002
6 HKU 776512M 1158250 Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions 2012/2013
7 HKU 7270/98M 705000 Interaction between the polyol pathway and non-enzymatic glycation in the pathogenesis of diabetic nephoropathy 1998/1999
8 HKU 1/98C 5500000 Understanding gene function and molecular bases of disease using transgenic and gene targeting technology 1998/1999
9 HKU 779707M 1258228 APPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation 2007/2008
10 HKU 7501/05M 1721828 Secretin: a putative neurosecretory hormone that regulates water homeostasis in the hypothalamus-pituitary-adrenal axis 2005/2006
11 HKU 777611M 890000 Molecular regulations of reactive nitrogen species inhibitors for preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in experimental cererbal ischemia-reperfersion models 2011/2012
12 HKU 7254/98M 1072000 A transgenic mouse model for a human hereditary neurodegenerative disorder of motor neuron, spinal and bulbal muscular atrophy, caused by trinucleotide CAG repeat expansion in the androgen receptor gene 1998/1999
13 HKU 7294/02M 1786000 Functional characterization of a novel liver-enriched transcription factor of the bZIP family 2002/2003
14 HKU 777610M 1084600 Elucidating caveolin-1 as a negative modulating protein for proliferation of neural stem/progenitor cells and neural differentiation in post-ischemic brain 2010/2011
15 HKU 7294/01M 841500 The role of chondroitin 6-sulfotransferase in post-traumatic regeneration of peripheral nerves 2001/2002
16 HKU 775008M 1020047 RAGE (receptor for advanced glycation end products), Abeta (beta-amyloid peptide) and ET-1 (endothelin-1)  probing their effects in glaucoma with transgenic mice over-expressing ET-1 in endothelial or glial cells 2008/2009
17 HKU6/CRF/11G 5625000 Strategic research of hormones and their receptors in the water homeostatic axis: from molecular mechanisms to anti-hypertensive drug design 2011/2012
18 HKU 4/05C 6500000 Genomic approaches to uncover functionally relevant signalling pathways in craniofacial development 2005/2006
19 HKU 7243/98M 980300 Growth and functions of human kidney tubular cells and transgenic mouse kidneys affected by mutated adult polycystic kidney disease gene, PKDl 1998/1999
20 HKU 218/95M 631000 To study the protective role of insulin-like growth factor-1 in neural degeneration using a transgenic mouse model 1995/1996
21 HKU 7240/97M 1211360 Targeted over-expression of endothelin-1 in astrocytes as a transgenic model to investigate its role in brain injury and blood-brain barrier function 1997/1998
22 HKU 774408M 1191369 Interactions of Reactive Nitrogen Species, Caveolins and Matrix Metalloproteinases: A Novel Signal Mechanism in Disruption of Blood Brain Barrier during Ischemic Stroke 2008/2009
23 HKU 7261/02M 816000 Investigating the role of a secreted protein sPIN-1 in the regulation of pancreatic [beta]-cell growth and differentiation 2002/2003
24 N_HKU 708/02 770982 Mechanism of Nogo-A inhibition of axonal regeneration 2002/2003
25 HKU 7268/98M 705000 The production of a transgenic mouse model of autoimmune thyroiditis and the study of induction of tolerance to an organ specific autoantigen in transgenic mice expressing thyroid peroxidase in the thymus 1998/1999
Principal Investigator
Project Code Amount Title Funding Year
1 HKU 764008M 1060726 Role of Epac1, cAMP-regulated guanine nucleotide exchange factor 1, in blood brain barrier maintenance, infarct and neurological deficits during ischemia/reperfusion injury 2008/2009
2 HKU 359/94M 503000 Transgenic mouse models to study the molecular basis of diabetic neuropathy 1994/1995
3 HKU 7327/03M 1356000 Molecular mechanisms of dementia associated with aging-related diseases, alzheimer's and multi-infarct 2003/2004
4 T13-607/12-R 480000 Stem Cell Strategy for Nervous System Disorders 2012/2013
5 HKU 220/95M 880000 Study of the functions of developmentally essential gene, endothelin-1, using two-tiered transgenic approach 1995/1996
6 HKU 7258/98M 705000 Generation of ligand-inducible knockout mouse model of endothelin-1 to study neural injury and protection and blood brain barrier maintenance 1998/1999
7 HKU 451/96M 692000 The cell type-specific knockout of endothelin-1 gene to understand its function 1996/1997
8 HKU 7313/04M 1669500 Genetic approaches to understand the pathogenesis of diabetic neuropathy: common, debilitating disease 2004/2005
9 HKU 7294/00M 1097100 Role of endothelial and astrocytic ET-1 in the pathogenesis of diabetic retinopathy, a major cause of blindness in man 2000/2001
10 HKU 7225/97M 686880 Targeted disruption of aldose reductase gene in mice to study its role in diabetic neuropathy 1997/1998
11 HKU 7504/06M 1374300 Conditional knockout of osmotic responsive element binding protein, OREBP/NFAT5/TonEBP, to study its role in brain edema and infarct after ischemic stroke: a leading cause of mortality and morbidity 2006/2007
12 BRI 96-I-2 460000 Schwann cell-specific inactivation of neuro-proteins, aldose reductase, to study its role in diabetic neuropathy 1996/1997
13 HKU 765212M 1200000 Molecular Basis for Diabetes-induced Painless and Painful Neuropathy, and Inability to Structurally and Functionally Recovery after Peripheral Nerve Injury 2012/2013
14 BRI 96-I-2 475480 Schwann cell-specific inactivation of neuro-proteins, aldose reductase, to study its role in diabetic neuropathy 1997/1998
15 HKU 318/93M 486000 Molecular basis for regeneration of central nervous system: a possible regulatory role of growth associated protein 1993/1994
16 HKU 7220/02M 2090000 Characterization of endothelin-1 gene manipulated mice for ischemic stroke, a leading cause of death and disability 2002/2003

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