Yao, KM

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Dr Yao, Kwok Ming 丘國明

Title:
Associate Professor

Department:

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3917 9275
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Dr Yao, Kwok Ming 丘國明

Title:
Associate Professor

Department:

Research Interests:(click to check for cognate researchers)

Also Cited As:
Yao, Kwok-ming

Biography

FOXM1 and regulation of cell proliferation and survival of cancer and stem cells. Dr. Yao was one of the co-discoverers of FOXM1 when he was a postdoctoral fellow at Genetics Institute, Inc. (Yao et la., 1997). His lab first demonstrated that FOXM1 over-expression stimulates cyclin B1 expression and enhances progression through the G2/M phase of the cell cycle (Leung et al., 2001). FOXM1 was later shown by Dr. Yao’s lab to be regulated by MAPK signaling, strongly indicating a pivotal role played by FOXM1 in mediating the growth promoting effect of mitogens (Ma et al., 2005). Further, Dr. Yao and his collaborators discovered that FOXM1 regulates the transcription of the estrogen receptor α in breast cancer cells (Madureira et al., 2006) and that FoxM1 counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression in MEFs (Li et al., 2008). Recently, Dr. Yao’s lab presented evidence to support the hypothesis that the b isoform, which is frequently over-expressed in cancers, represents a more active form of FOXM1 (Lam et al., 2013).Furthermore, Dr. Yao has collaborated with Dr. David Chan (co-I) and Prof. Ngan, clinical colleagues at the Department of Obstetrics and Gynecology, HKU, to show that FOXM1 is involved in the regulation of cervical cancer progression (Chan et al., 2008) and the migration/invasion of ovarian cancer cells (Lok et al., 2011).

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
WONG, SY
2014-09-01Runner-up in Visual Sciences, The 3rd Li Ka Shing Foundation International Research Student Forum, Sep 25, 2014: Joint Shantou International Eye Center, The Chinese University of Hong Kong
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
Since 2012Regular memberInternational Society of Stem Cell Research
Since 2008Regular memberAmerican Society for Biochemistry and Molecular Biology (ASBMB)
Since 1992Regular memberAmerican Association for the Advancement of Science
Since 1997Regular memberThe Genetics Society of America
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