Dr Yao, Kwok Ming 丘國明
FOXM1 and regulation of cell proliferation and survival of cancer and stem cells. Dr. Yao was one of the co-discoverers of FOXM1 when he was a postdoctoral fellow at Genetics Institute, Inc. (Yao et la., 1997). His lab first demonstrated that FOXM1 over-expression stimulates cyclin B1 expression and enhances progression through the G2/M phase of the cell cycle (Leung et al., 2001). FOXM1 was later shown by Dr. Yao’s lab to be regulated by MAPK signaling, strongly indicating a pivotal role played by FOXM1 in mediating the growth promoting effect of mitogens (Ma et al., 2005). Further, Dr. Yao and his collaborators discovered that FOXM1 regulates the transcription of the estrogen receptor α in breast cancer cells (Madureira et al., 2006) and that FoxM1 counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression in MEFs (Li et al., 2008). Recently, Dr. Yao’s lab presented evidence to support the hypothesis that the b isoform, which is frequently over-expressed in cancers, represents a more active form of FOXM1 (Lam et al., 2013).Furthermore, Dr. Yao has collaborated with Dr. David Chan (co-I) and Prof. Ngan, clinical colleagues at the Department of Obstetrics and Gynecology, HKU, to show that FOXM1 is involved in the regulation of cervical cancer progression (Chan et al., 2008) and the migration/invasion of ovarian cancer cells (Lok et al., 2011).
|Term Period||Position||Professional Societies|
|Since 2012||Regular member||International Society of Stem Cell Research|
|Since 2008||Regular member||American Society for Biochemistry and Molecular Biology (ASBMB)|
|Since 1992||Regular member||American Association for the Advancement of Science|
|Since 1997||Regular member||The Genetics Society of America|
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