Name Card

Emeritus Professor Lai, Ching Lung 黎青龍

Title:

Honorary Clinical Professor

Department:

Department of Medicine

Faculty:

Li Ka Shing Faculty of Medicine

Principal Investigator

Project Code	Project Title	Amount	Funding Year
N/A	A phase IIb extension study of LdT (Telbivudine), lamivudine, or LdT plus lamivudine in patients with chronic hepatitis B who have completed study NV-02B-003	980359	2002
N/A	A placebo-controlled study of lamivudine (LAI) and Intron A (IFN) in patients with chronic hepatitis B virus (HBV) infection who are interferon non-responders	0	1995
N/A	A continuation of the double-blind, placebo-controlled study to determine the safety and efficacy of long-term (3 years) lamivudine (LAI) in patients with chronic hepatitis B virus (HBV).	0	1995
N/A	Use of the hepatitis B recombinant DNA yeast vaccine in patients with chronic renal failure on dialysis	0	1987
N/A	A clinical trial on [gamma] interferon for the treatment of chronic hepatitis B	93600	1987
N/A	Colchicine in hepatitis B related cirrhosis	0	1987
N/A	Phase II trial of lamivudine in Chinese chronic hepatitis B carriers	0	1993
N/A	Evaluation of IFN alfa-2b, alone and following prednisone withdrawal in Asian children with chronic type B hepatitis	156000	1987
N/A	In vitro antigen-specific antibody response to hepatitis B surface antigen (HBs Ag) in subjects positive for antibody against HBs Ag, vaccinees and in chronic hepatitis B related disease	16400	1989
N/A	The use of interferon in intraarterial therapy for patients with inoperable hepatocellular carcinoma (HCC)	0	1997
N/A	Hepatotoxicity of antituberculous drugs in hepatitis B carriers	0	1996
N/A	Interferon (IFN) in inoperable hepatocellular carcinoma (HCC)	0	1985
N/A	Use of the hepatitis B recombinant DNA yeast vaccine (produced by SK and F) in children	0	1986
N/A	A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials	627204	2002
N/A	A phase I/II dose escalation study to evaluate the pharmacokinetics, safety, and antiviral activity of beta-L-2'-Deoxycytidine-3'-monovaline ester (monoval-LdC) in adults with chronic hepatitis B	294276	2002
N/A	Interferon (IFN) with and without steroid in HBsAg carrier children	78000	1987
N/A	A phase III study of the safety and antiviral activity of entecavir vs lamivudine in adults with chronic hepatitis B infection who are positive for hepatitis B e antigen	957263	2000
N/A	The efficacy of interferon alone vs interferon plus ribarivin in the treatment of chronic hepatitis C	0	1997
N/A	Adoptive immunotherapy of hepatocelular carcinoma using interleukin 2 and lymphokine-activated killer cells	78000	1988
N/A	Comparison between the hepatitis B recombinant DNA vaccines produce by Johnson & Johnson & by MSD	202800	1987
N/A	Natural history of chronic hepatitis B carriers	0	1996
N/A	Comparison of two hepatitis B recombinant DNA yeast vaccine in children	0	1987
N/A	Multicentre trial of lamivudine in Chinese chronic hepatitis B carriers	0	1994
N/A	A planned investigation into liver cancer - the second commonest cause of cancer death in Hong Kong (Phase II)	4500000	1995
N/A	Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials	334152	2002
N/A	A phase II, open-label, multinational, multi-centre, sequential group, dose-escalation study to assess the safety and antiviral activity of LB80380 for 24 weeks in patients with chronic hepatitis B who have developed lamivudine-resistant (YMDD mutant) HBV	678714	2003
N/A	A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis	146305	2003
N/A	A phase III study of the comparison of entecavir to lamivudine in chronic hepatitis B subjects with incomplete response to current lamivudine therapy	49989	2001

Co-Investigator

Project Code	Project Title	Amount	Funding Year
2141213	Provision of serum quantitative hepatitis B surface antigen measurements to optimize disease monitoring and risk stratification of chronic hepatitis B	717780	2014
HKU 782809M	Genetic and epigenetic analyses of occult hepatitis B virus infection	661290	2009
06060572	Hepatitis B virus array for genotyping and mutation detection	800000	2006
13120782	Hepatitis B X protein primary structure and epigenetic regulation of HBV replication	967880	2013
2151210	Provision of Controlled Attenuated Parameter Measurements for the Identification of Non-Alcoholic Fatty Liver Disease and Disease Monitoring of Liver Cirrhosis	189900	2015
N/A	A planned investigation into liver cancer, the second commonest cause of cancer death in Hong Kong	2800000	1991
01030421	Hepatitis B or Hepatitis C viral infection and genotypes - which subgroup is more prone to the development of hepatocellular carcinoma? A systematic review	359654	2003
08070852	Identification of hepatitis B virus DNA polymerase sequences to predict virological response to entecavir therapy	583052	2008
ITS/112/02	Development of novel nucleic acid therapeutics for viral infection and cancer	2313472	2002
12111282	Mutational analysis of the hepatitis B core protein DNA-binding domain and its role in HBV transcription regulation	997880	2012
N/A	Evaluation of interferon-[alpha]2 B in chronic type B hepatitis in Asian adults and children	1750842	1988
09080682	Application of COLD-PCR sequencing for the early detection of HBV antiviral drug resistant mutations	566624	2008
N/A	Adopted immune transfer in hepatitis B carrier (HBsAg +ve) state patient receiving allogeneic bone marrow transplant from hepatitis B surface Ab (HBsAb) positive marrow donor	0	1995
HKU 7289/97M	Comparative genomic hybridization in the detection of genetic alterations in hepatocellular carcinoma	686880	1997
09080862	Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with Chronic Hepatitis B	699110	2009
05060741	Health-related quality of life and health preference of patients with chronic Hepatitis B infections	400209	2006
N/A	A randomised controlled trial of recombinant [alpha] interferon in chronic hepatitis B in Chinese adults and children	420000	1986
N/A	A randomised trial of 2 vs 5 ug doses of (HEVAC B) hepatitis B vaccine in family member of HBsAg carriers; a study on the immunogenic response of anti-HBc positive subjects to 5 ug doses of HEVAC B	90000	1986
08090791	Perceptions of cancer risk and self-care practices: A comparison of groups at different risk for cancers	682630	2010
12111842	Risk of Hepatitis B Reactivation after Hematopoietic Stem Cell Transplantation in Donors and Recipients with Prior HBV Exposure	951960	2012
HKU 1/06C	Molecular pathology of liver cancer - a multidisciplinary study	6400000	2006
HKU 781108M	Transmissibility of hepatitis B virus infection from blood donors with occult hepatitis B infection	566592	2008