Dr Lung, Hong Lok 龍康樂
- My current projects are mainly focused on the cancer genetics and the associated tumor microenvironment of nasopharyngeal carcinoma (NPC). We have previously identified some NPC tumor suppressor genes (TSGs) including THY1, TSLC1, ADAMTS9, and CRYAB by using the functional complementation approach and the subsequent gene profiling and genotyping analyses. We are characterizing their tumor suppressive function and association with angiogenesis in NPC. My role is to investigate the mechanistic analysis of some tumor suppressors. By understanding which oncogenic signalling pathways the tumor suppressors are counteracting, potential therapeutic targets for NPC will be identified and relevant inhibitors will be tested for anti-cancer therapy. On the other hand, polymorphism analysis of a recently identified TSG, Serum Amyloid A 1 (SAA1), and its associations with NPC and esophageal squamous cell carcinoma (ESCC) risk are my other major research interest. In addition, I am also interested to investigate whether the aggressive/metastatic phenotype of NPC cell lines is associated with tumor hypoxia.
I graduated from the University of Western Sydney with a bachelor’s degree of Technology Management and obtained my PhD from The Chinese University of Hong Kong. After being a postdoctoral fellow at The Chinese University of Hong Kong and a research associate at The Hong Kong University of Science & Technology, I joined the Department of Clinical Oncology at the University of Hong Kong as a Research Assistant Professor in 2009 and was promoted as an Assistant Professor in 2012.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2014-02-01||Seed Funding Programme for Basic Research - “Establishment of human nasopharyngeal carcinoma in 3D invasion and angiogenesis organotypic culture to study hypoxia-induced tumor invasion and angiogenesis” HK$47,900||Research Achievement|
|Term Period||Position||Professional Societies|
|2001-present||Council member||Hong Kong Society for Immunology|
|2013-present||Reviewer board member||Bioprotocol|
|My major interest is to identify and study tumor suppressor genes in nasopharyngeal carcinoma (NPC) by the combination of mono-chromosome transfer, gene expression profiling, and genotyping techniques. The underlining mechanisms of tumor suppression, which include the anti-angiogenic, apoptosis-inducing, and growth inhibitory effects are currently investigated. Polymorphism analysis of some of our tumor suppressor genes and their associations with NPC risk are my other major research interest.||Identification and study of tumor suppressor genes in nasopharyngeal carcinoma|
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