Nicotine and its active metabolite in the tumorigenesis of colon cancer
Professor Cho, Chi Hin (Principal investigator)
Professor Chan Kelvin K.C. (Co-Investigator)
Nicotine, tumorigenesis, colon cancer
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To investigate the differential roles of nicotinic receptor and B-adrenoceptor in the tumorigenesis of colon cancer cells; to investigate pathogenic signal pathway of nicotine and its metabol NNK in the development of colon cancer; to investigate the therapeutic strategy to target the oncogenes involved in this carcinogenic pathway to treat and prevent cancer formation especially in cigarette smokers.