Nicotine and its active metabolite in the tumorigenesis of colon cancer


Grant Data
Project Title
Nicotine and its active metabolite in the tumorigenesis of colon cancer
Principal Investigator
Professor Cho, Chi Hin   (Principal investigator)
Co-Investigator(s)
Professor Chan Kelvin K.C.   (Co-Investigator)
Duration
24
Start Date
2004-11-01
Completion Date
2006-10-31
Amount
939968
Conference Title
Presentation Title
Keywords
Nicotine, tumorigenesis, colon cancer
Discipline
Pharmacology/Toxicology
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7312/04M
Grant Type
General Research Fund (GRF)
Funding Year
2004/2005
Status
Completed
Objectives
To investigate the differential roles of nicotinic receptor and B-adrenoceptor in the tumorigenesis of colon cancer cells; to investigate pathogenic signal pathway of nicotine and its metabol NNK in the development of colon cancer; to investigate the therapeutic strategy to target the oncogenes involved in this carcinogenic pathway to treat and prevent cancer formation especially in cigarette smokers.