Protective effect of thrombopoietin on iron-induced cardiomyopathy


Grant Data
Project Title
Protective effect of thrombopoietin on iron-induced cardiomyopathy
Principal Investigator
Dr Yang, Mo   (Principal investigator)
Duration
24
Start Date
2007-07-01
Completion Date
2009-06-30
Amount
190000
Conference Title
Presentation Title
Keywords
thalassaemia, Iron, thrombopoietin, cardiomyopathy
Discipline
Blood/Hematology,Paediatrics
Sponsor
Other projects
Grant Type
Children's Thalassaemia Foundation - General Awards
Funding Year
2007/2008
Status
On-going
Objectives
To investigate the pro-apoptotic effect of iron overload in cardiomyocytes and this effect may be mediated by caspase dependent pathway; to confirm the hypothesis that TPO has a protective effect on iron-induced apoptosis in cardiomyocytes via the activation of Akt signaling pathway.