Protective effect of thrombopoietin on iron-induced cardiomyopathy
Dr Yang, Mo (Principal investigator)
thalassaemia, Iron, thrombopoietin, cardiomyopathy
Children's Thalassaemia Foundation - General Awards
To investigate the pro-apoptotic effect of iron overload in cardiomyocytes and this effect may be mediated by caspase dependent pathway; to confirm the hypothesis that TPO has a protective effect on iron-induced apoptosis in cardiomyocytes via the activation of Akt signaling pathway.