Effects of GC content and mutational pressure on exon length


Grant Data
Project Title
Effects of GC content and mutational pressure on exon length
Principal Investigator
Dr Xia, Xuhua   (Principal investigator)
Duration
24
Start Date
2001-10-01
Completion Date
2003-09-30
Amount
536030
Conference Title
Presentation Title
Discipline
Genetic Disease
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7212/01M
Grant Type
General Research Fund (GRF)
Funding Year
2001/2002
Status
Completed
Objectives
To evaluate the effect of GC content on exon length by using the huge amount of molecular data already available in molecular databanks; to test the prediction that the effect of GC content on exon length is more pronounced in the mitochondrial genomes than in the nuclear genomes; to assess the frequency of the gene truncation event due to nonsence mutations and the gene elongation event due to stop codons mutating to sense codons; to implement new analytical tools in my program DAMBE, which will be distributed free to reserchers.