The effect of DNA methylation on codon substitution and codon usage bias
Dr Xia, Xuhua (Principal investigator)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
The project will quantify the effect of DNA methylation on nucleotide, codon and amino acid substitution patters; integrate the methylation effect on codon usage into current hypotheses on codon usage bias; and develop computer programs for comparative sequence anaylsis by automating analytical procedures such as data retrieval from GenBank, data compilation and manipulation, phylogenetic reconstruction, and phylogeny-based comparative analysis.