Molecular characterization of a novel regulated domain in mammalian cell nuclei
Dr Opstelten, Davina (Principal investigator)
Croucher Foundation - Research Grants
Through the use of hybridoma technology, novel domains in mammalian cell nuclei have been discovered. Most intruigingly, the domains, called HIS55 antigen domains, show a tissue-specific and differentiation-stage-dependent expression pattern in rat, man and other mammals. The project aims at the molecular characterization of these regulated domains. Knowledge of the structure and composition of the domains will contribute to understanding their function. It will contribute significantly to the understanding of nuclear function, in particular the regulation of gene expression. Scientists are fascinated with transcriptional control, as it plays a fundamental role in a wide variety of biological transitions which result in phenotypic changes in cells.