Molecular characterization of a novel regulated domain in mammalian cell nuclei


Grant Data
Project Title
Molecular characterization of a novel regulated domain in mammalian cell nuclei
Principal Investigator
Dr Opstelten, Davina   (Principal investigator)
Duration
55
Start Date
1993-12-01
Completion Date
1998-06-30
Amount
660000
Conference Title
Presentation Title
Grant Type
Croucher Foundation - Research Grants
Funding Year
1993/1994
Status
Completed
Objectives
Through the use of hybridoma technology, novel domains in mammalian cell nuclei have been discovered. Most intruigingly, the domains, called HIS55 antigen domains, show a tissue-specific and differentiation-stage-dependent expression pattern in rat, man and other mammals. The project aims at the molecular characterization of these regulated domains. Knowledge of the structure and composition of the domains will contribute to understanding their function. It will contribute significantly to the understanding of nuclear function, in particular the regulation of gene expression. Scientists are fascinated with transcriptional control, as it plays a fundamental role in a wide variety of biological transitions which result in phenotypic changes in cells.