Cellular and subcellular mechanisms of vascular smooth muscle contraction: calcium signalling and membrane transduction


Grant Data
Project Title
Cellular and subcellular mechanisms of vascular smooth muscle contraction: calcium signalling and membrane transduction
Principal Investigator
Professor Kwan, David Chiu Yin   (Principal investigator)
Duration
48
Start Date
1993-09-01
Completion Date
1997-08-31
Amount
1691000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 319/93M
Grant Type
General Research Fund (GRF)
Funding Year
1993/1994
Status
Completed
Objectives
The functional relationship between two major [alpha]-adrenoceptor subtypes and the validity of further subclassification of [alpha]1-subtypes in vascular smooth muscle; characterization of prejunctional (in paravascular nerve and varicosities) vs postjunctional receptors (in the vascular smooth muscle cells of arteries and veins); membrane transduction and calcium signalling processes in endothelial cells and smooth muscle cells using novel pharmacological tools that interfers with intracellular calcium sequestration; application to endotoxin-induced vascular changes.