Application of DNA-based techniques to the evaluation of bone marrow donors in a Chinese population
Dr Hawkins, Brian Roy (Principal investigator)
Professor Bradley (Co-principal investigator)
HKU Project Code
UK/Hong Kong Joint Research Scheme
Various DNA-based laboratory techniques have been developed by the U.K. team to assess the compatibility of unrelated BMT donors and recipients (3,4). Some of these techniques are currently available in Hong Kong but others are not. The initial aim of this project is to establish all these techniques in Hong Kong with the assistance of the University of Bristol team. Having set up the techniques it will be necessary to jointly evaluate their efficacy in predicting the outcome of unrelated BMT in the genetically distinct populations of U.K. and Hong Kong. This will require the establishment of a protocols and evaluative criteria. The evaluation process itself will be a long term project requiring patient follow-up over several years. Whilst the project has immediate benefits in exchanging technology, therefore, it will also form the basis of a long-term collaborative study with clear implications for the clinical management of BMT patients in both geographical areas.