Hepatitis B virus DNA (HBV-DNA) in Chinese patients with chronic HBV infection and hepatocellular carcinoma (HCC)
Dr Lok, Anna Suk Fong (Principal investigator)
HKU Project Code
Strategic Research Fund (UPGC)
To determine the serum HBV-DNA levels and the molecular state (episomal and/or integrated) HBV-DNA in liver tissue in patients with chronic HBV infection and HCC; to characterize and clone the viral/host integration sites in patients with chronic hepatitis B, cirrhosis and HCC and to determine the mechanism leading to carcinogenesis.