Development of PASA as a screening diagnostic


Grant Data
Project Title
Development of PASA as a screening diagnostic
Principal Investigator
Dr Lam, Veronica Min Sien   (Principal investigator)
Duration
24
Start Date
1996-07-01
Completion Date
1998-06-30
Amount
751116
Conference Title
Presentation Title
HKU Project Code
AF/69/96
Grant Type
Industrial Support Fund
Funding Year
1996/1997
Status
Completed
Objectives
G6PD deficiency represents the most common human enzymopathy, the clinical manifestations of which are generally triggered by the environment. Hence the affected/at risk need to be diagnosed and counselled. We aim to develop a simple amplification system which will selectively amplify the appropriate allele(s) under defined conditions. This method depends on the use of designed oligonucleotides, but when developed, it will provide a simple diagnostic for screening the G6PD genotype of newborns in Hong Kong, south China and many southeast Asian countries. This detection system could be further developed as a diagnostic kit. When detail structure-function relationship of G6PD becomes available, the G6PD genotype information will enable health personnel to predict the severity of the disease when triggered by particular environment agent(s).