Delayed cardioprotection of preconditioning with ischaemia and [kappa]-opioid: Ca2+ homeostatsis, signal transduction and clinical implications
Professor Wong, Tak Ming (Principal investigator)
Professor He Guo-Wei (Co-Investigator)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To establish the involvement of [kappa]-opioid receptor in the delayed cardioprotection of IP in animal and human models in vivo and in vitro; to determine the role of PKC and the related mechanisms - K(ATP) channels and NHE - in mediating the delayed protection of [kappa]-opioid receptor; to determine whether the protein effectors are involved in delayed cardioprotection of preconditioning with [kappa]-opioid receptor stimulation; to study the Ca+2 homeostasis involved in delayed cardioprotection of preconditioning with ischaemia or [kappa]-opioid receptor agonist.