Delayed cardioprotection of preconditioning with ischaemia and [kappa]-opioid: Ca2+ homeostatsis, signal transduction and clinical implications


Grant Data
Project Title
Delayed cardioprotection of preconditioning with ischaemia and [kappa]-opioid: Ca2+ homeostatsis, signal transduction and clinical implications
Principal Investigator
Professor Wong, Tak Ming   (Principal investigator)
Co-Investigator(s)
Professor He Guo-Wei   (Co-Investigator)
Duration
36
Start Date
1999-09-01
Completion Date
2002-08-31
Amount
709500
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7192/99M
Grant Type
General Research Fund (GRF)
Funding Year
1999/2000
Status
Completed
Objectives
To establish the involvement of [kappa]-opioid receptor in the delayed cardioprotection of IP in animal and human models in vivo and in vitro; to determine the role of PKC and the related mechanisms - K(ATP) channels and NHE - in mediating the delayed protection of [kappa]-opioid receptor; to determine whether the protein effectors are involved in delayed cardioprotection of preconditioning with [kappa]-opioid receptor stimulation; to study the Ca+2 homeostasis involved in delayed cardioprotection of preconditioning with ischaemia or [kappa]-opioid receptor agonist.