Patch clamp studies on the epididymis


Grant Data
Project Title
Patch clamp studies on the epididymis
Principal Investigator
Professor Wong, Patrick Yee Ding   (Principal investigator)
Start Date
1988-05-01
Amount
20000
Conference Title
Presentation Title
Grant Type
Sun Yat Sen Fund
Funding Year
1989/1990
Status
Completed
Objectives
The epididymis is known to secrete anions and fluid when stimulated with secretomotor agonists. Anion secretion plays an important role in the maintenance of a normal fluid environment within the epididymal duct in which spermatozoa are bathed. It is thought that defective secretory mechanism in the epididymis would lead to obstruction of the epididymal duct by inspissated material, hence giving rise to the obstructive azoospermia seen in cystic fibrosis, Young Syndrome and cases of unexplained male infertility. The aim of the present work is to use the patch clamp technique to characterize ion channels on the epididymal cells. This work will shed light on the secretory mechanism at the molecular level.