Immunopathogenesis of tuberculosis in Hong Kong
Dr Higgins, David Anthony (Principal investigator)
Dr Skamene (Co-Investigator)
Mr Bloom (Co-Investigator)
Dr Lowrie (Co-Investigator)
Dr Chan (Co-Investigator)
World Health Organization (WHO) - General Award
To study immune parameters in tuberculosis patients; to identify humoral and cellular suppressor influences; to compare the immune responsiveness of peripheral blood cells and pleural effusion cells in tuberculosis patients; to ascertain whether any deficiency in production or activity of cytokines is localized to the site of infection; and to establish Epstein-Barr virus-transformed B cell lines from members of multiple case families for analysis with probes for recently-discovered genes conferring resistance or susceptibility to mycobacterial infections.