Release of newly-formed B lymphocytes from the bone marrow: molecular interactions with the adluminal side of sinusoidal endothelium
Grant Data
Project Title
Release of newly-formed B lymphocytes from the bone marrow: molecular interactions with the adluminal side of sinusoidal endothelium
Principal Investigator
Dr Opstelten, Davina
(Principal Investigator)
Duration
12
Start Date
1993-07-01
Amount
20000
Conference Title
Release of newly-formed B lymphocytes from the bone marrow: molecular interactions with the adluminal side of sinusoidal endothelium
Presentation Title
Keywords
null
Discipline
N/A
HKU Project Code
N/A
Grant Type
Pauline Chan Medical Research Fund
Funding Year
1993
Status
Completed
Objectives
B lymphocytes are continuously produced in the bone marrow parenchyma. They leave the marrow by transit through the sinusoidal wall. Sinusoidal lumina are often loaded with newly-formed B lymphocytes, and are hard to displace by perfusion, suggesting that they actually adhere to the adluminal side of endothelium. A stage of adherence might serve selective mechanisms such as tolerance induction. We propose to study molecular interactions involved.