The early phase of repertoire development in normal B lymphocyte genesis


Grant Data
Project Title
The early phase of repertoire development in normal B lymphocyte genesis
Principal Investigator
Dr Opstelten, Davina   (Principal investigator)
Duration
37
Start Date
1990-06-01
Completion Date
1993-06-30
Amount
966000
Conference Title
Presentation Title
HKU Project Code
HKU 17/90
Grant Type
University Grants Committee - General Award
Funding Year
1990/1991
Status
Completed
Objectives
By use of in situ hybridization and a chimeric animal model, to answer the following questions with regard to immunoglobulin repertoire development in rodent bone marrow: 1) Does the population of pre-B cells use the IgVh gene families in frequencies differing from those in the population of IgM+ B lymphocytes? 2) How is the Vh gene usage within clones of B lymphoid cells? 3) Is the Vh gene family usage influenced by microenvironmental factors?