Identification and utilization of tumor specific serological markers for the early detection of esophageal cancer


Grant Data
Project Title
Identification and utilization of tumor specific serological markers for the early detection of esophageal cancer
Principal Investigator
Dr Cao, Liang   (Principal investigator)
Co-Investigator(s)
Emeritus Professor Ng Mun Hon   (Co-Investigator)
Duration
36
Start Date
1995-07-01
Completion Date
1998-06-30
Amount
0
Conference Title
Presentation Title
Keywords
cancer
Discipline
Others - Medicine, Dentistry and Health
Sponsor
Other projects
Grant Type
Other Funding Scheme
Funding Year
1995/1996
Status
Completed
Objectives
It is estimated that 50,000 people develop esophageal cancer each year in the developed countries, and at least 10 times of that number in developing countries, especially in China. Only about 10% of these patients recover from the disease after treatment. This is largely because early symptoms of the cancer is innocuous, and therefore it is not diagnosed until the disease is at an advanced stage. The proposal aims to develop a test for early diagnosis of this cancer in order to improve patients' chance of recovery. The project will be carried out in 3 stages. The first is to identify genes that are specifically expressed in the cancer at high levels. The second is to develop tests to detect the products encoded by these genes. The third is to carry out clinical trails to determine which of these tests can be used for early diagnosis with adequate sensitive and specificity.