Characterization of the role of liver cancer stem cell marker, CD133 in promoting chromosome instability in hepatocarcinogenesis
Grant Data
Project Title
Characterization of the role of liver cancer stem cell marker, CD133 in promoting chromosome instability in hepatocarcinogenesis
Principal Investigator
Dr Ching, Yick Pang
(Principal Investigator (PI))
Duration
48
Start Date
2018-01-01
Completion Date
2021-12-31
Amount
1025393
Conference Title
Characterization of the role of liver cancer stem cell marker, CD133 in promoting chromosome instability in hepatocarcinogenesis
Presentation Title
Keywords
aneuploidy, CD133, Centrosome, Chromosome instability, HCC
Discipline
Cancer,Cell Biology
Panel
Biology and Medicine (M)
HKU Project Code
17113117
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 Investigation of the tumorigenic activity of CD133 in HCC cells i) Investigation of the role of CD133 in HCC tumourigenicity ii) Investigation of the anti-apoptotic activity of CD133 2 Investigation of the effect of CD133 on chromosome instability i) Characterization of the effect of CD133 in aneuploidy ii) Investigation of the role of CD133 in supernumerary centrosome iii) Investigation of the potential target(s) regulated by CD133 in chromosome instability 3 Evaulation of the role of TAX1BP2/CD133 in chromosome instability and hepatocarcinogenesis i) Characterization of the regulation of TAX1BP2 by CD133 ii) Investigation of the effect of CD133 on the tumour suppressor activity of TAX1BP2 iii) Investigation of the role of TAX1BP2/CD133 in HCC chemo-resistance