Development of a Degradable Hybrid Bioactive Coating for Osteoporotic Fracture Fixation Implants (Clustered Project #4)


Grant Data
Project Title
Development of a Degradable Hybrid Bioactive Coating for Osteoporotic Fracture Fixation Implants (Clustered Project #4)
Principal Investigator
Dr Yeung, Kelvin Wai Kwok   (Project coordinator)
Co-Investigator(s)
Dr Wong Hoi Man   (Co-Investigator)
Dr Fok Margaret Woon Man   (Co-Investigator)
Duration
16
Start Date
2016-03-01
Completion Date
2017-06-30
Amount
201600
Conference Title
Presentation Title
Keywords
Degradable Hybrid Bioactive Coating, Osteoporotic Fracture Fixation Implants
Discipline
Others - Medicine, Dentistry and Health
Panel
Medicine
HKU Project Code
InP/025/16
Grant Type
Innovation and Technology Fund Internship Programme
Funding Year
2015/2016
Status
On-going
Objectives
The bioactive coating comprising the FDA approved biodegradable polymer called polycaprolactone and magnesium micro-particles can reinforce the fixation at the bone-implant interface. Most importantly, the release of magnesium ions upon controlled coating degradation can stimulate local bone formation and hence reduce the healing time of the bone fracture. Our previous studies demonstrated that a small amount of magnesium ions (i.e. 50-100ppm) could up-regulate the in vitro bone cell activities and promote local bone formation in vivo. Hence, the technology innovation of this project is to control the release of magnesium ions at the level shown in our previous works. If successful, this newly developed degradable bioactive coating is expected to reduce the amount of implant-related post-operative complications in osteoporotic fracture patients, thereby greatly minimising the burden on patients and social costs due to hospitalisation.