Detection and characterization of antibody-dependent cell-mediated cytotoxicity (ADCC) responses against human H7N9 virus in humans and mice


Grant Data
Project Title
Detection and characterization of antibody-dependent cell-mediated cytotoxicity (ADCC) responses against human H7N9 virus in humans and mice
Principal Investigator
Dr Poon, Lit Man Leo   (Principal investigator)
Co-Investigator(s)
Dr Doak Sophie Alessandra   (Co-Investigator)
Duration
24
Start Date
2016-05-01
Completion Date
2018-04-30
Amount
1199608
Conference Title
Presentation Title
Keywords
Influenza, H7N9, ADCC, Antibody, Vaccine
Discipline
Others - Medicine, Dentistry and Health
Panel
Medicine
HKU Project Code
15141052
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2015/2016
Status
On-going
Objectives
also determine whether seasonal influenza vaccinations can induce cross reactive ADCC responses against H7N9 HA. In addition, we shall identify non-neutralizing viral epitopes that might control ADCC activities and study the potential effects of ADCC using mouse models.