Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment

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Grant Data
Project Title
Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment
Principal Investigator
Professor Chan, Danny   (Principal Investigator (PI))
Co-Investigator(s)
Dr Legeai-Mallet Laurence   (Co-principal investigator)
Dr To Michael Kai Tsun   (Co-Investigator)
Duration
24
Start Date
2016-01-01
Amount
60000
Conference Title
Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment
Presentation Title
Keywords
Cellular changes, drug treatment, FGFR3 mutations, spinal curvature
Discipline
Developmental Biology,Disease Model Development
HKU Project Code
F-HKU701/15T
Grant Type
France/Hong Kong Joint Research Scheme - Travel Grants
Funding Year
2015
Status
Completed
Objectives
1. Detailed assessment of intervertebral disc changes in achondroplasia mice; 2. Study the impact of FGFR3 mutations in the fate of endplate hypertrophic chondrocytes; 3. Study the impact of drug therapy using C-type natriuretic peptide on spinal defects