Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment


Grant Data
Project Title
Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment
Principal Investigator
Professor Chan, Danny   (Principal investigator)
Co-Investigator(s)
Dr To Michael Kai Tsun   (Co-Investigator)
Dr Legeai-Mallet Laurence   (Co-principal investigator)
Duration
24
Start Date
2016-01-01
Completion Date
2017-12-31
Amount
60000
Conference Title
Presentation Title
Keywords
Cellular changes, spinal curvature, FGFR3 mutations, drug treatment
Discipline
Developmental Biology,Disease Model Development
Panel
Medicine
Sponsor
France/HK Joint Research Scheme
HKU Project Code
F-HKU701/15T
Grant Type
France/Hong Kong Joint Research Scheme - Travel Grants
Funding Year
2015/2016
Status
On-going
Objectives
1. Detailed assessment of intervertebral disc changes in achondroplasia mice; 2. Study the impact of FGFR3 mutations in the fate of endplate hypertrophic chondrocytes; 3. Study the impact of drug therapy using C-type natriuretic peptide on spinal defects