Backbone cleavage of peptide radical cations induced by nucleophilic attack on aromatic side chains in vacuo: From adjacent to non-adjacent amide bonds


Grant Data
Project Title
Backbone cleavage of peptide radical cations induced by nucleophilic attack on aromatic side chains in vacuo: From adjacent to non-adjacent amide bonds
Principal Investigator
Dr Chu, Ivan Keung   (Principal investigator)
Co-Investigator(s)
Dr Laskin Julia   (Co-Investigator)
Professor Hopkinson Alan C   (Co-Investigator)
Duration
36
Start Date
2015-08-15
Completion Date
2018-08-14
Amount
706972
Conference Title
Presentation Title
Keywords
Radical peptide, tandem mass spectrometry, gas-phase chemsitry, energetics, ion-chemistry
Discipline
Mass Spectrometry
Panel
Physical Sciences (P)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17306015
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To investigate the fundamental factors governing the peptide-to-aromatic side chain cyclization through calculations [using density functional theory (DFT) and Rice–Ramsperger–Kassel–Marcus (RRKM) modelling] and experiments; 3 To determine the selected energetics and dynamics of bond cleavages in peptide radical cations induced by nucleophilic attack by heteroatoms in an amide group on (adjacent or non-adjacent) aromatic side chains, both experimentally and computationally.